Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1018580..1019235 Replicon chromosome
Accession NZ_CP034030
Organism Neisseria gonorrhoeae strain FQ02

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag EGH17_RS05935 Protein ID WP_003691083.1
Coordinates 1018580..1018999 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag EGH17_RS05940 Protein ID WP_003688410.1
Coordinates 1018999..1019235 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGH17_RS05915 1013814..1015355 - 1542 WP_003697015.1 multidrug efflux MFS transporter -
EGH17_RS05920 1015503..1016282 + 780 WP_003688416.1 (Fe-S)-binding protein -
EGH17_RS05925 1016279..1016980 + 702 WP_003688414.1 lactate utilization protein C -
EGH17_RS05930 1016977..1018431 + 1455 WP_003701282.1 iron-sulfur cluster-binding protein -
EGH17_RS05935 1018580..1018999 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
EGH17_RS05940 1018999..1019235 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
EGH17_RS05945 1019441..1019638 - 198 WP_033910354.1 IS3 family transposase -
EGH17_RS05950 1019683..1020261 - 579 WP_003688041.1 IS3 family transposase -
EGH17_RS05955 1020266..1020694 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
EGH17_RS05965 1020906..1021292 + 387 Protein_1024 IS110 family transposase -
EGH17_RS05975 1021675..1022565 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
EGH17_RS05980 1022576..1023742 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
EGH17_RS05985 1023814..1024101 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T114975 WP_003691083.1 NZ_CP034030:c1018999-1018580 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T114975 NZ_CP034030:c1018999-1018580 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT114975 WP_003688410.1 NZ_CP034030:c1019235-1018999 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT114975 NZ_CP034030:c1019235-1018999 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References