Detailed information of TA system TA114974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1635115..1635800
• Replicon: chromosome
• Accession: NZ_CP034028
• Organism: Neisseria gonorrhoeae strain FQ04

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: EGH18_RS09590
• Protein ID: WP_003689143.1
• Coordinates: 1635618..1635800 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: EGH18_RS09585
• Protein ID: WP_003691454.1
• Coordinates: 1635115..1635516 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGH18_RS09530	1630160..1630375	-	216	WP_003691538.1	hypothetical protein	-
EGH18_RS09535	1630427..1630918	-	492	WP_010359966.1	siphovirus Gp157 family protein	-
EGH18_RS09540	1630915..1631097	-	183	WP_003691535.1	hypothetical protein	-
EGH18_RS09545	1631237..1631923	-	687	WP_012503754.1	hypothetical protein	-
EGH18_RS09550	1631992..1632153	-	162	WP_003702497.1	hypothetical protein	-
EGH18_RS09555	1632150..1632425	-	276	WP_064661611.1	hypothetical protein	-
EGH18_RS09560	1632578..1632910	-	333	WP_003687946.1	hypothetical protein	-
EGH18_RS09565	1633051..1633338	-	288	WP_082278089.1	hypothetical protein	-
EGH18_RS09570	1633335..1633811	-	477	WP_012504141.1	hypothetical protein	-
EGH18_RS09575	1633844..1634044	-	201	WP_003692842.1	hypothetical protein	-
EGH18_RS09580	1634234..1635016	+	783	WP_003689146.1	hypothetical protein	-
EGH18_RS09585	1635115..1635516	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGH18_RS09590	1635618..1635800	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGH18_RS09595	1635970..1636788	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
EGH18_RS09600	1636785..1637483	-	699	WP_003689139.1	hypothetical protein	-
EGH18_RS09605	1637722..1638432	-	711	WP_124693305.1	helix-turn-helix transcriptional regulator	-
EGH18_RS09610	1638548..1638736	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
EGH18_RS09615	1638816..1638971	+	156	WP_003691446.1	hypothetical protein	-
EGH18_RS09620	1638948..1639136	-	189	WP_003706568.1	hypothetical protein	-
EGH18_RS09625	1639309..1639536	+	228	WP_047949281.1	helix-turn-helix domain-containing protein	-
EGH18_RS09630	1639533..1640513	+	981	WP_124693320.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1619931..1653411	33480

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T114974 WP_003689143.1 NZ_CP034028:c1635800-1635618 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T114974 NZ_CP034028:c1635800-1635618 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT114974 WP_003691454.1 NZ_CP034028:c1635516-1635115 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT114974 NZ_CP034028:c1635516-1635115 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2