Detailed information of TA system TA114970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1643595..1644280
• Replicon: chromosome
• Accession: NZ_CP034024
• Organism: Neisseria gonorrhoeae strain FQ35

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: EGH14_RS09585
• Protein ID: WP_003689143.1
• Coordinates: 1644098..1644280 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: EGH14_RS09580
• Protein ID: WP_003691454.1
• Coordinates: 1643595..1643996 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGH14_RS09535	1639012..1639194	-	183	WP_003691535.1	hypothetical protein	-
EGH14_RS09540	1639334..1640020	-	687	WP_082298587.1	hypothetical protein	-
EGH14_RS09545	1640089..1640250	-	162	WP_047924242.1	hypothetical protein	-
EGH14_RS09550	1640247..1640522	-	276	WP_017146994.1	hypothetical protein	-
EGH14_RS09555	1640675..1641007	-	333	WP_047922517.1	hypothetical protein	-
EGH14_RS09565	1641532..1642314	+	783	WP_003689146.1	hypothetical protein	-
EGH14_RS09570	1642404..1642820	-	417	WP_003693479.1	hypothetical protein	-
EGH14_RS09575	1642829..1643413	-	585	WP_003693477.1	SocA family protein	-
EGH14_RS09580	1643595..1643996	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGH14_RS09585	1644098..1644280	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGH14_RS09590	1644450..1645268	-	819	WP_124724061.1	DUF3037 domain-containing protein	-
EGH14_RS09595	1645543..1646298	-	756	WP_003693472.1	LexA family transcriptional regulator	-
EGH14_RS09600	1646435..1646620	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
EGH14_RS09605	1646710..1646865	+	156	WP_124723990.1	hypothetical protein	-
EGH14_RS09610	1646842..1647030	-	189	WP_124723991.1	hypothetical protein	-
EGH14_RS09615	1647203..1647430	+	228	WP_003693879.1	helix-turn-helix domain-containing protein	-
EGH14_RS09620	1647548..1648612	+	1065	WP_003689134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1628029..1662113	34084

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T114970 WP_003689143.1 NZ_CP034024:c1644280-1644098 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T114970 NZ_CP034024:c1644280-1644098 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT114970 WP_003691454.1 NZ_CP034024:c1643996-1643595 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT114970 NZ_CP034024:c1643996-1643595 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2