Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 656511..657166 Replicon chromosome
Accession NZ_CP034024
Organism Neisseria gonorrhoeae strain FQ35

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag EGH14_RS04050 Protein ID WP_003691083.1
Coordinates 656747..657166 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag EGH14_RS04045 Protein ID WP_003688410.1
Coordinates 656511..656747 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGH14_RS04010 651645..651932 + 288 WP_124723933.1 hypothetical protein -
EGH14_RS04015 652004..653170 + 1167 WP_003693287.1 ADP-forming succinate--CoA ligase subunit beta -
EGH14_RS04020 653181..654071 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
EGH14_RS04025 654309..654840 - 532 Protein_677 IS110 family transposase -
EGH14_RS04030 655052..655480 + 429 WP_010360042.1 helix-turn-helix domain-containing protein -
EGH14_RS04035 655485..656063 + 579 WP_003688041.1 IS3 family transposase -
EGH14_RS04040 656108..656305 + 198 WP_033910354.1 IS3 family transposase -
EGH14_RS04045 656511..656747 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
EGH14_RS04050 656747..657166 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
EGH14_RS04055 657315..658769 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
EGH14_RS04060 658766..659467 - 702 WP_003688414.1 lactate utilization protein C -
EGH14_RS04065 659464..660243 - 780 WP_003688416.1 (Fe-S)-binding protein -
EGH14_RS04070 660391..661932 + 1542 WP_003697015.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T114969 WP_003691083.1 NZ_CP034024:656747-657166 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T114969 NZ_CP034024:656747-657166 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT114969 WP_003688410.1 NZ_CP034024:656511-656747 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT114969 NZ_CP034024:656511-656747 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References