Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1639344..1640029 | Replicon | chromosome |
| Accession | NZ_CP034022 | ||
| Organism | Neisseria gonorrhoeae strain FQ36 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | EGH13_RS09655 | Protein ID | WP_003689143.1 |
| Coordinates | 1639847..1640029 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | EGH13_RS09650 | Protein ID | WP_003691454.1 |
| Coordinates | 1639344..1639745 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGH13_RS09595 | 1634401..1634616 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| EGH13_RS09600 | 1634668..1635159 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| EGH13_RS09605 | 1635156..1635338 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| EGH13_RS09610 | 1635478..1636164 | - | 687 | WP_012503754.1 | hypothetical protein | - |
| EGH13_RS09615 | 1636233..1636394 | - | 162 | WP_003691530.1 | hypothetical protein | - |
| EGH13_RS09620 | 1636391..1636666 | - | 276 | WP_003703838.1 | hypothetical protein | - |
| EGH13_RS09625 | 1636819..1637151 | - | 333 | WP_033910864.1 | hypothetical protein | - |
| EGH13_RS09630 | 1637292..1637567 | - | 276 | WP_050172639.1 | hypothetical protein | - |
| EGH13_RS09635 | 1637564..1638040 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| EGH13_RS09640 | 1638073..1638273 | - | 201 | WP_047920804.1 | hypothetical protein | - |
| EGH13_RS09645 | 1638463..1639245 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| EGH13_RS09650 | 1639344..1639745 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| EGH13_RS09655 | 1639847..1640029 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| EGH13_RS09660 | 1640199..1641017 | - | 819 | WP_025455900.1 | DUF3037 domain-containing protein | - |
| EGH13_RS09665 | 1641014..1641712 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| EGH13_RS09670 | 1641951..1642661 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| EGH13_RS09675 | 1642777..1642965 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| EGH13_RS13615 | 1643045..1643305 | + | 261 | WP_165865284.1 | hypothetical protein | - |
| EGH13_RS09690 | 1643538..1643765 | + | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| EGH13_RS09695 | 1643762..1644766 | + | 1005 | WP_050172491.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1624173..1657656 | 33483 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T114968 WP_003689143.1 NZ_CP034022:c1640029-1639847 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T114968 NZ_CP034022:c1640029-1639847 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT114968 WP_003691454.1 NZ_CP034022:c1639745-1639344 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT114968 NZ_CP034022:c1639745-1639344 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|