Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1635848..1636533 | Replicon | chromosome |
| Accession | NZ_CP034018 | ||
| Organism | Neisseria gonorrhoeae strain FQ82 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | EGH11_RS09590 | Protein ID | WP_003689143.1 |
| Coordinates | 1636351..1636533 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | EGH11_RS09585 | Protein ID | WP_003691454.1 |
| Coordinates | 1635848..1636249 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EGH11_RS09530 | 1630893..1631108 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| EGH11_RS09535 | 1631160..1631651 | - | 492 | WP_010359966.1 | siphovirus Gp157 family protein | - |
| EGH11_RS09540 | 1631648..1631830 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| EGH11_RS09545 | 1631970..1632656 | - | 687 | WP_012503754.1 | hypothetical protein | - |
| EGH11_RS09550 | 1632725..1632886 | - | 162 | WP_003702497.1 | hypothetical protein | - |
| EGH11_RS09555 | 1632883..1633158 | - | 276 | WP_064661611.1 | hypothetical protein | - |
| EGH11_RS09560 | 1633311..1633643 | - | 333 | WP_003687946.1 | hypothetical protein | - |
| EGH11_RS09565 | 1633784..1634071 | - | 288 | WP_082278089.1 | hypothetical protein | - |
| EGH11_RS09570 | 1634068..1634544 | - | 477 | WP_012504141.1 | hypothetical protein | - |
| EGH11_RS09575 | 1634577..1634777 | - | 201 | WP_003692842.1 | hypothetical protein | - |
| EGH11_RS09580 | 1634967..1635749 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| EGH11_RS09585 | 1635848..1636249 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| EGH11_RS09590 | 1636351..1636533 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| EGH11_RS09595 | 1636703..1637521 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| EGH11_RS09600 | 1637518..1638216 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| EGH11_RS09605 | 1638455..1639165 | - | 711 | WP_124693305.1 | helix-turn-helix transcriptional regulator | - |
| EGH11_RS09610 | 1639281..1639469 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| EGH11_RS09615 | 1639549..1639704 | + | 156 | WP_003691446.1 | hypothetical protein | - |
| EGH11_RS09620 | 1639681..1639869 | - | 189 | WP_003706568.1 | hypothetical protein | - |
| EGH11_RS09625 | 1640042..1640269 | + | 228 | WP_047949281.1 | helix-turn-helix domain-containing protein | - |
| EGH11_RS09630 | 1640266..1641231 | + | 966 | WP_124693283.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1620664..1654129 | 33465 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T114965 WP_003689143.1 NZ_CP034018:c1636533-1636351 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T114965 NZ_CP034018:c1636533-1636351 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT114965 WP_003691454.1 NZ_CP034018:c1636249-1635848 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT114965 NZ_CP034018:c1636249-1635848 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|