Detailed information of TA system TA114965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1635848..1636533
• Replicon: chromosome
• Accession: NZ_CP034018
• Organism: Neisseria gonorrhoeae strain FQ82

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: EGH11_RS09590
• Protein ID: WP_003689143.1
• Coordinates: 1636351..1636533 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: EGH11_RS09585
• Protein ID: WP_003691454.1
• Coordinates: 1635848..1636249 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGH11_RS09530	1630893..1631108	-	216	WP_003691538.1	hypothetical protein	-
EGH11_RS09535	1631160..1631651	-	492	WP_010359966.1	siphovirus Gp157 family protein	-
EGH11_RS09540	1631648..1631830	-	183	WP_003691535.1	hypothetical protein	-
EGH11_RS09545	1631970..1632656	-	687	WP_012503754.1	hypothetical protein	-
EGH11_RS09550	1632725..1632886	-	162	WP_003702497.1	hypothetical protein	-
EGH11_RS09555	1632883..1633158	-	276	WP_064661611.1	hypothetical protein	-
EGH11_RS09560	1633311..1633643	-	333	WP_003687946.1	hypothetical protein	-
EGH11_RS09565	1633784..1634071	-	288	WP_082278089.1	hypothetical protein	-
EGH11_RS09570	1634068..1634544	-	477	WP_012504141.1	hypothetical protein	-
EGH11_RS09575	1634577..1634777	-	201	WP_003692842.1	hypothetical protein	-
EGH11_RS09580	1634967..1635749	+	783	WP_003689146.1	hypothetical protein	-
EGH11_RS09585	1635848..1636249	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGH11_RS09590	1636351..1636533	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGH11_RS09595	1636703..1637521	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
EGH11_RS09600	1637518..1638216	-	699	WP_003689139.1	hypothetical protein	-
EGH11_RS09605	1638455..1639165	-	711	WP_124693305.1	helix-turn-helix transcriptional regulator	-
EGH11_RS09610	1639281..1639469	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
EGH11_RS09615	1639549..1639704	+	156	WP_003691446.1	hypothetical protein	-
EGH11_RS09620	1639681..1639869	-	189	WP_003706568.1	hypothetical protein	-
EGH11_RS09625	1640042..1640269	+	228	WP_047949281.1	helix-turn-helix domain-containing protein	-
EGH11_RS09630	1640266..1641231	+	966	WP_124693283.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1620664..1654129	33465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T114965 WP_003689143.1 NZ_CP034018:c1636533-1636351 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T114965 NZ_CP034018:c1636533-1636351 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT114965 WP_003691454.1 NZ_CP034018:c1636249-1635848 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT114965 NZ_CP034018:c1636249-1635848 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2