Detailed information of TA system TA114963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1635108..1635793
• Replicon: chromosome
• Accession: NZ_CP034016
• Organism: Neisseria gonorrhoeae strain FQ84

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: EGH15_RS09595
• Protein ID: WP_003689143.1
• Coordinates: 1635611..1635793 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: EGH15_RS09590
• Protein ID: WP_003691454.1
• Coordinates: 1635108..1635509 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGH15_RS09535	1630153..1630368	-	216	WP_003691538.1	hypothetical protein	-
EGH15_RS09540	1630420..1630911	-	492	WP_010359966.1	siphovirus Gp157 family protein	-
EGH15_RS09545	1630908..1631090	-	183	WP_003691535.1	hypothetical protein	-
EGH15_RS09550	1631230..1631916	-	687	WP_012503754.1	hypothetical protein	-
EGH15_RS09555	1631985..1632146	-	162	WP_003702497.1	hypothetical protein	-
EGH15_RS09560	1632143..1632418	-	276	WP_064661611.1	hypothetical protein	-
EGH15_RS09565	1632571..1632903	-	333	WP_003687946.1	hypothetical protein	-
EGH15_RS09570	1633044..1633331	-	288	WP_082278089.1	hypothetical protein	-
EGH15_RS09575	1633328..1633804	-	477	WP_012504141.1	hypothetical protein	-
EGH15_RS09580	1633837..1634037	-	201	WP_003692842.1	hypothetical protein	-
EGH15_RS09585	1634227..1635009	+	783	WP_003689146.1	hypothetical protein	-
EGH15_RS09590	1635108..1635509	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGH15_RS09595	1635611..1635793	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGH15_RS09600	1635963..1636781	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
EGH15_RS09605	1636778..1637476	-	699	WP_003689139.1	hypothetical protein	-
EGH15_RS09610	1637715..1638425	-	711	WP_124693305.1	helix-turn-helix transcriptional regulator	-
EGH15_RS09615	1638541..1638729	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
EGH15_RS09620	1638809..1638964	+	156	WP_003691446.1	hypothetical protein	-
EGH15_RS09625	1638941..1639129	-	189	WP_003706568.1	hypothetical protein	-
EGH15_RS09630	1639302..1639529	+	228	WP_047949281.1	helix-turn-helix domain-containing protein	-
EGH15_RS09635	1639526..1640494	+	969	WP_115306933.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1619924..1653392	33468

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T114963 WP_003689143.1 NZ_CP034016:c1635793-1635611 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T114963 NZ_CP034016:c1635793-1635611 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT114963 WP_003691454.1 NZ_CP034016:c1635509-1635108 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT114963 NZ_CP034016:c1635509-1635108 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2