114962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 947756..948411 Replicon chromosome
Accession NZ_CP034016
Organism Neisseria gonorrhoeae strain FQ84

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag EGH15_RS05530 Protein ID WP_003691083.1
Coordinates 947756..948175 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag EGH15_RS05535 Protein ID WP_003688410.1
Coordinates 948175..948411 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGH15_RS05510 942990..944531 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
EGH15_RS05515 944679..945458 + 780 WP_003688416.1 (Fe-S)-binding protein -
EGH15_RS05520 945455..946156 + 702 WP_003688414.1 lactate utilization protein C -
EGH15_RS05525 946153..947607 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
EGH15_RS05530 947756..948175 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
EGH15_RS05535 948175..948411 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
EGH15_RS05540 948617..948814 - 198 WP_033910354.1 IS3 family transposase -
EGH15_RS05545 948859..949437 - 579 WP_003688041.1 IS3 family transposase -
EGH15_RS05550 949442..949870 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
EGH15_RS05560 950082..950468 + 387 Protein_961 IS110 family transposase -
EGH15_RS05565 950851..951741 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
EGH15_RS05570 951752..952918 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
EGH15_RS05575 952990..953277 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T114962 WP_003691083.1 NZ_CP034016:c948175-947756 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T114962 NZ_CP034016:c948175-947756 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT114962 WP_003688410.1 NZ_CP034016:c948411-948175 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT114962 NZ_CP034016:c948411-948175 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References