Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4644571..4646111 Replicon chromosome
Accession NZ_CP034015
Organism Shewanella livingstonensis strain LMG 19866

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EGC82_RS20320 Protein ID WP_124732722.1
Coordinates 4644571..4645872 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EGC82_RS20325 Protein ID WP_124732362.1
Coordinates 4645875..4646111 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGC82_RS20290 4640448..4640603 - 156 Protein_3904 transcriptional regulator -
EGC82_RS20295 4640609..4641052 + 444 WP_124732358.1 TIGR00645 family protein -
EGC82_RS20300 4641097..4641435 - 339 WP_124732359.1 hypothetical protein -
EGC82_RS20305 4641868..4642287 - 420 WP_124732360.1 hypothetical protein -
EGC82_RS20310 4642369..4643088 - 720 WP_124732361.1 ATPase -
EGC82_RS21390 4643587..4644222 - 636 WP_208646913.1 hypothetical protein -
EGC82_RS20320 4644571..4645872 - 1302 WP_124732722.1 HipA domain-containing protein Toxin
EGC82_RS20325 4645875..4646111 - 237 WP_124732362.1 helix-turn-helix domain-containing protein Antitoxin
EGC82_RS20330 4646498..4646641 - 144 Protein_3912 type II toxin-antitoxin system HipA family toxin -
EGC82_RS20335 4646692..4647711 - 1020 WP_164839175.1 helix-turn-helix domain-containing protein -
EGC82_RS20340 4648164..4648604 + 441 WP_124732364.1 hypothetical protein -
EGC82_RS20345 4648900..4649937 + 1038 WP_124732365.1 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48266.39 Da        Isoelectric Point: 5.2906

>T114961 WP_124732722.1 NZ_CP034015:c4645872-4644571 [Shewanella livingstonensis]
MSTAEKLTLDMHLGDQIIGELSFDPATETFTVQYSHSWQQGGFPISPMIPLEGTANSHQIAMFLVNLLPENKGLEYLIES
LGVSRGNTFALIRGIGLDTAGAIAFSPTGTLLPATALRAISVDEVIKRIEDPQLWPMEVWDGKPRLSVAGVQSKLNLFYN
GNTFGFGDGSLASTHILKFAPYRHLVINEFLTMSLAKAIGNDVANVDIVEFGQHKSLCVERFDRRYISEAQKVLRRHMID
SCQALGFSVSKKYERNFGTGRDVKGIREGVSFARLFSLASECTNPAAAKQNMLQWALFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVNVAMYKDFEQEMAMAIDDEFDPNKIYAYQLASFAEELNLPRLLLVSNLTKMATKIEQVIDDVIAMLPALA
KDEHAFVADYRQQLMTRCQRYLDMTAEVKAVEL

Download         Length: 1302 bp

>T114961 NZ_CP034015:c4645872-4644571 [Shewanella livingstonensis]
ATGAGTACCGCTGAAAAACTGACTTTAGATATGCATCTGGGCGATCAGATAATTGGTGAGCTGTCATTTGATCCAGCGAC
TGAGACATTCACGGTCCAATACTCTCATAGTTGGCAACAAGGTGGTTTCCCTATTTCGCCAATGATTCCCCTAGAGGGAA
CCGCTAATAGTCATCAAATTGCGATGTTTTTAGTCAACCTATTACCTGAAAATAAAGGCTTAGAATACTTAATTGAATCG
CTAGGGGTTTCTCGTGGTAATACATTTGCGCTTATTCGTGGTATCGGCCTTGATACCGCGGGTGCAATCGCTTTTTCGCC
AACAGGAACATTACTACCGGCAACAGCCTTAAGGGCGATAAGTGTTGATGAAGTGATTAAGCGAATTGAAGATCCGCAGC
TATGGCCAATGGAAGTGTGGGACGGAAAACCAAGGCTGTCAGTCGCTGGGGTGCAGTCTAAATTAAACCTGTTTTATAAT
GGCAATACTTTTGGCTTTGGTGACGGTTCGCTGGCATCCACACATATTTTGAAGTTTGCACCATACCGTCATTTAGTGAT
TAACGAGTTTCTTACCATGAGCTTGGCTAAGGCTATTGGTAACGATGTTGCTAATGTCGATATTGTCGAGTTTGGTCAAC
ATAAATCCCTTTGTGTCGAACGCTTTGATCGTCGTTATATATCAGAGGCTCAAAAAGTCTTGAGACGACACATGATTGAT
AGCTGCCAAGCACTGGGTTTTAGTGTGAGCAAAAAATACGAGCGTAACTTTGGCACCGGTCGTGATGTGAAAGGTATTCG
AGAGGGCGTAAGCTTTGCTCGTTTGTTTAGCCTCGCCAGTGAGTGCACTAATCCTGCAGCTGCTAAACAAAATATGCTGC
AGTGGGCTTTATTTAATTTACTTAGCGGTAATGCTGATGCCCATGGCAAAAACTACTCATTTTTCATGACTCCCACAGGG
ATGGTACCGACCCCCTGGTATGACTTAGTCAATGTGGCAATGTATAAGGATTTCGAACAGGAGATGGCAATGGCTATCGA
TGATGAATTCGACCCTAATAAAATTTATGCTTATCAACTGGCCTCGTTCGCCGAGGAACTGAATTTACCACGACTATTAT
TAGTCAGTAATTTAACAAAGATGGCAACCAAAATAGAGCAAGTGATAGATGATGTGATTGCGATGCTTCCAGCGTTGGCT
AAAGATGAACATGCTTTTGTGGCAGATTATCGCCAGCAACTCATGACAAGGTGCCAACGCTATCTTGATATGACGGCTGA
AGTAAAGGCTGTTGAGTTGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8414.78 Da        Isoelectric Point: 9.0132

>AT114961 WP_124732362.1 NZ_CP034015:c4646111-4645875 [Shewanella livingstonensis]
MTSALNQQSLGLLIKETRNKAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILNGLGINILATKPSDADSSGWY

Download         Length: 237 bp

>AT114961 NZ_CP034015:c4646111-4645875 [Shewanella livingstonensis]
ATGACATCTGCACTCAATCAACAATCCTTGGGTTTACTCATTAAAGAAACCAGAAACAAAGCAGCACTGACTCAAGATGT
GGCGGCGATGTTGTGTGGCGTGACCAAAAAGACCTTAATCCGTGTTGAGAAAGGCGAAGATGTTTATATCTCGACAGTGT
TCAAAATTCTTAATGGCTTGGGTATTAACATTTTGGCGACGAAGCCCAGTGATGCTGATTCGAGTGGGTGGTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References