Detailed information of TA system TA114959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3744828..3745344
• Replicon: chromosome
• Accession: NZ_CP034015
• Organism: Shewanella livingstonensis strain LMG 19866

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGC82_RS16160
• Protein ID: WP_124013264.1
• Coordinates: 3744828..3745097 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EGC82_RS16165
• Protein ID: WP_124013263.1
• Coordinates: 3745090..3745344 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGC82_RS16120	3740279..3740545	+	267	WP_124731668.1	DUF4209 domain-containing protein	-
EGC82_RS16125	3740723..3742318	-	1596	WP_124730991.1	IS66 family transposase	-
EGC82_RS16130	3742402..3742749	-	348	WP_124730990.1	IS66 family insertion sequence element accessory protein TnpB	-
EGC82_RS16135	3742743..3743072	-	330	WP_124730989.1	IS66 family insertion sequence hypothetical protein	-
EGC82_RS16140	3743350..3743610	-	261	WP_124013271.1	DUF2442 domain-containing protein	-
EGC82_RS16145	3743573..3743809	-	237	WP_124013270.1	DUF4160 domain-containing protein	-
EGC82_RS16150	3743893..3744075	-	183	WP_124013269.1	hypothetical protein	-
EGC82_RS16155	3744072..3744584	-	513	WP_124731669.1	hypothetical protein	-
EGC82_RS16160	3744828..3745097	-	270	WP_124013264.1	Txe/YoeB family addiction module toxin	Toxin
EGC82_RS16165	3745090..3745344	-	255	WP_124013263.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EGC82_RS16175	3745872..3746075	+	204	WP_164839150.1	Fic family protein	-
EGC82_RS16180	3746355..3746609	+	255	WP_124731670.1	hypothetical protein	-
EGC82_RS16185	3746868..3747194	+	327	WP_124731671.1	hypothetical protein	-
EGC82_RS16190	3747428..3747655	-	228	Protein_3111	type II toxin-antitoxin system HipA family toxin	-
EGC82_RS16195	3747833..3747940	-	108	Protein_3112	IS982 family transposase	-
EGC82_RS16200	3748270..3749583	-	1314	WP_124731672.1	type II toxin-antitoxin system HipA family toxin	-
EGC82_RS16205	3749583..3749864	-	282	WP_124013259.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10695.15 Da
• Isoelectric Point: 9.4084

>T114959 WP_124013264.1 NZ_CP034015:c3745097-3744828 [Shewanella livingstonensis]
MSSRMRLLSWTDDAWNDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDHAI
TLISCRYHY

Nucleotide

• Length: 270 bp

>T114959 NZ_CP034015:c3745097-3744828 [Shewanella livingstonensis]
ATGAGTAGTCGCATGCGTTTACTTTCCTGGACTGACGATGCTTGGAATGACTATTTGTACTGGCAAACTCAAGACAAGAA
AACACTAAAGCGAATTAATAAGCTGATCAATGATGTTAAACGTTCGCCATTTGAGGGCATAGGTAAACCAGAGCCACTAA
AGGAAAACTTATCTGGCTTTTGGTCGCGTCGTATTGATGACACAAATAGGCTTGTTTATGCTGTTGATGATCACGCTATC
ACGCTAATTTCGTGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9456.60 Da
• Isoelectric Point: 4.7914

>AT114959 WP_124013263.1 NZ_CP034015:c3745344-3745090 [Shewanella livingstonensis]
MKIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT114959 NZ_CP034015:c3745344-3745090 [Shewanella livingstonensis]
ATGAAGATCGTATCTTTTACTGAAGCTAGAAACAGTCTCAAAGCCGTTTTAGACGGTGTCGTTAATGATGCTGACACAAC
CGTAATAACTCGCCGTGACTCGGAAGATGCAGTGGTTATGTCTCTAGACTATTACAATAGTCTTATGGAGACAGTTCATT
TACTTCGCTCGCCTGAAAATGCCGAGCATTTAAATCGTTCCATAGCGCAGTATCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG