Detailed information of TA system TA114958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 118717..119483
• Replicon: chromosome
• Accession: NZ_CP034015
• Organism: Shewanella livingstonensis strain LMG 19866

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EGC82_RS00545
• Protein ID: WP_124729039.1
• Coordinates: 118986..119483 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q07W31
• Locus tag: EGC82_RS00540
• Protein ID: WP_011639367.1
• Coordinates: 118717..118989 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGC82_RS00525	114462..115694	+	1233	WP_124729037.1	imidazolonepropionase	-
EGC82_RS00530	115952..116728	+	777	WP_124732522.1	haloacid dehalogenase type II	-
EGC82_RS00535	116901..118562	+	1662	WP_124729038.1	amidohydrolase	-
EGC82_RS00540	118717..118989	+	273	WP_011639367.1	DUF1778 domain-containing protein	Antitoxin
EGC82_RS00545	118986..119483	+	498	WP_124729039.1	GNAT family N-acetyltransferase	Toxin
EGC82_RS00550	119768..120646	-	879	WP_124729040.1	restriction endonuclease	-
EGC82_RS00555	121325..121564	-	240	WP_124729041.1	YdcH family protein	-
EGC82_RS00560	121746..123611	+	1866	WP_124729042.1	DUF885 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18590.21 Da
• Isoelectric Point: 7.9876

>T114958 WP_124729039.1 NZ_CP034015:118986-119483 [Shewanella livingstonensis]
IMNTVLLDKAKHDRNRFNCGIDALNNYLKVMASQQAKKDNSRTFILEDDNDNSYIIGFYTLTMTPIDLKALPDKLQKKYQ
SSTSGGLIARLAIDDRYKGQGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLN

Nucleotide

• Length: 498 bp

>T114958 NZ_CP034015:118986-119483 [Shewanella livingstonensis]
ATAATGAATACGGTACTTTTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATTGACGCTCTTAATAACTA
CCTAAAAGTCATGGCGAGTCAGCAAGCGAAGAAAGACAACAGCAGAACTTTCATTTTAGAAGATGATAACGATAACTCGT
ATATCATTGGCTTTTATACCTTAACAATGACACCCATTGACCTAAAGGCTCTGCCGGATAAGCTGCAGAAAAAATACCAA
TCATCAACCTCTGGCGGCCTTATAGCCCGCTTAGCAATCGATGACCGCTATAAAGGCCAAGGCTTTGGCGAATGGTTACT
TATTGATGCACTACGAAAACTGCTAGCGGCAAGTGATAGCGTAGCATTCCCAGTCGTCATTGTTGACGCAAAAGATGGCG
CAAAACACTTCTACGAACGCTATGGATTTCAGGCTTTTCAAGACGCAGAAAACAAACTGTTCATCACCATTGCAGATGTA
AGAGCAAGTTTAAACTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9767.26 Da
• Isoelectric Point: 6.2988

>AT114958 WP_011639367.1 NZ_CP034015:118717-118989 [Shewanella livingstonensis]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQIIEREQVLKLSQTDAMLLMEALDSPATPNSKLKT
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT114958 NZ_CP034015:118717-118989 [Shewanella livingstonensis]
ATGGCGACTACTTTACCTCGCATCACTGCTAGAGTTGATGTCGACACCCAAGATTTACTGACAAAGGCAGCAGCAATCGC
TGGTATGTCGAGTATTAATTCATTTGTGCTAAGTGCCGCAATCGAAAAAGCCAAACAAATCATTGAGCGTGAACAAGTAC
TAAAACTAAGTCAAACAGATGCGATGTTGCTTATGGAAGCACTAGACAGTCCAGCAACACCAAACTCAAAACTCAAAACG
GCTTCGGAACGTTACGAAAGCAAAACCCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A3G8LNV6