Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 855470..855947 Replicon chromosome
Accession NZ_CP034014
Organism Staphylococcus aureus strain P1D1C1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EFD67_RS04060 Protein ID WP_000052076.1
Coordinates 855470..855658 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EFD67_RS04065 Protein ID WP_001059690.1
Coordinates 855687..855947 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD67_RS04030 851464..851985 + 522 WP_000824482.1 hypothetical protein -
EFD67_RS04035 852326..853012 + 687 WP_000141557.1 thermonuclease family protein -
EFD67_RS04040 853369..853569 + 201 WP_001059082.1 cold-shock protein -
EFD67_RS04045 854061..854279 - 219 WP_000005886.1 hypothetical protein -
EFD67_RS04050 854341..854625 - 285 WP_001004399.1 hypothetical protein -
EFD67_RS04055 854713..855282 - 570 WP_001106658.1 hypothetical protein -
EFD67_RS04060 855470..855658 - 189 WP_000052076.1 hypothetical protein Toxin
EFD67_RS04065 855687..855947 - 261 WP_001059690.1 hypothetical protein Antitoxin
EFD67_RS04070 856288..856491 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EFD67_RS04075 856488..856724 - 237 WP_000349581.1 hypothetical protein -
EFD67_RS04080 856949..857530 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EFD67_RS04085 857603..858220 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
EFD67_RS04090 858375..858869 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EFD67_RS04095 859268..859690 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EFD67_RS04100 859838..860554 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T114940 WP_000052076.1 NZ_CP034014:c855658-855470 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T114940 NZ_CP034014:c855658-855470 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT114940 WP_001059690.1 NZ_CP034014:c855947-855687 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT114940 NZ_CP034014:c855947-855687 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References