Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 1942003..1942779 Replicon chromosome
Accession NZ_CP034005
Organism Staphylococcus aureus strain P1D7C1

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag EFD70_RS09400 Protein ID WP_000031108.1
Coordinates 1942003..1942155 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag EFD70_RS09405 Protein ID WP_001251224.1
Coordinates 1942180..1942779 (-) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD70_RS09385 1938205..1939026 + 822 WP_000669376.1 RluA family pseudouridine synthase -
EFD70_RS09390 1939479..1940864 - 1386 WP_000116228.1 class II fumarate hydratase -
EFD70_RS09395 1941060..1941455 - 396 WP_000901023.1 hypothetical protein -
EFD70_RS09400 1942003..1942155 - 153 WP_000031108.1 hypothetical protein Toxin
EFD70_RS09405 1942180..1942779 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
EFD70_RS09410 1942938..1943408 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EFD70_RS09415 1943413..1944540 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
EFD70_RS09420 1944691..1945413 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EFD70_RS09425 1945406..1946863 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T114892 WP_000031108.1 NZ_CP034005:c1942155-1942003 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T114892 NZ_CP034005:c1942155-1942003 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT114892 WP_001251224.1 NZ_CP034005:c1942779-1942180 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT114892 NZ_CP034005:c1942779-1942180 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X5E2E6


Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References