Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 900446..900923 Replicon chromosome
Accession NZ_CP033987
Organism Staphylococcus aureus strain P2D1C1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EFD76_RS04465 Protein ID WP_000052076.1
Coordinates 900446..900634 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EFD76_RS04470 Protein ID WP_001059690.1
Coordinates 900663..900923 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD76_RS04435 896440..896961 + 522 WP_000824482.1 hypothetical protein -
EFD76_RS04440 897302..897988 + 687 WP_000141557.1 thermonuclease family protein -
EFD76_RS04445 898345..898545 + 201 WP_001059082.1 cold-shock protein -
EFD76_RS04450 899037..899255 - 219 WP_000005886.1 hypothetical protein -
EFD76_RS04455 899317..899601 - 285 WP_001004399.1 hypothetical protein -
EFD76_RS04460 899689..900258 - 570 WP_001106658.1 hypothetical protein -
EFD76_RS04465 900446..900634 - 189 WP_000052076.1 hypothetical protein Toxin
EFD76_RS04470 900663..900923 - 261 WP_001059690.1 hypothetical protein Antitoxin
EFD76_RS04475 901264..901467 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EFD76_RS04480 901464..901700 - 237 WP_000349581.1 hypothetical protein -
EFD76_RS04485 901925..902506 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EFD76_RS04490 902579..903196 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
EFD76_RS04495 903351..903845 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EFD76_RS04500 904244..904666 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EFD76_RS04505 904814..905530 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T114796 WP_000052076.1 NZ_CP033987:c900634-900446 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T114796 NZ_CP033987:c900634-900446 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT114796 WP_001059690.1 NZ_CP033987:c900923-900663 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT114796 NZ_CP033987:c900923-900663 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References