Detailed information of TA system TA114788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2187531..2188060
• Replicon: chromosome
• Accession: NZ_CP033982
• Organism: Staphylococcus aureus strain P2D8C1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EFD77_RS11050
• Protein ID: WP_000621175.1
• Coordinates: 2187531..2187893 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: EFD77_RS11055
• Protein ID: WP_000948331.1
• Coordinates: 2187890..2188060 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD77_RS11030	2184510..2185280	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
EFD77_RS11035	2185255..2185734	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
EFD77_RS11040	2185736..2186062	-	327	WP_001052491.1	anti-sigma factor antagonist	-
EFD77_RS11045	2186181..2187182	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
EFD77_RS11050	2187531..2187893	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EFD77_RS11055	2187890..2188060	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
EFD77_RS11060	2188145..2189293	-	1149	WP_001281154.1	alanine racemase	-
EFD77_RS11065	2189359..2189718	-	360	WP_000581197.1	holo-ACP synthase	-
EFD77_RS11070	2189722..2190213	-	492	WP_001205912.1	PH domain-containing protein	-
EFD77_RS11075	2190200..2191783	-	1584	WP_001294626.1	PH domain-containing protein	-
EFD77_RS11080	2191776..2192255	-	480	WP_001287087.1	hypothetical protein	-
EFD77_RS11085	2192463..2193023	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T114788 WP_000621175.1 NZ_CP033982:c2187893-2187531 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T114788 NZ_CP033982:c2187893-2187531 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT114788 WP_000948331.1 NZ_CP033982:c2188060-2187890 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT114788 NZ_CP033982:c2188060-2187890 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1