Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 900446..900923 Replicon chromosome
Accession NZ_CP033982
Organism Staphylococcus aureus strain P2D8C1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EFD77_RS04475 Protein ID WP_000052076.1
Coordinates 900446..900634 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EFD77_RS04480 Protein ID WP_001059690.1
Coordinates 900663..900923 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD77_RS04445 896440..896961 + 522 WP_000824482.1 hypothetical protein -
EFD77_RS04450 897302..897988 + 687 WP_000141557.1 thermonuclease family protein -
EFD77_RS04455 898345..898545 + 201 WP_001059082.1 cold-shock protein -
EFD77_RS04460 899037..899255 - 219 WP_000005886.1 hypothetical protein -
EFD77_RS04465 899317..899601 - 285 WP_001004399.1 hypothetical protein -
EFD77_RS04470 899689..900258 - 570 WP_001106658.1 hypothetical protein -
EFD77_RS04475 900446..900634 - 189 WP_000052076.1 hypothetical protein Toxin
EFD77_RS04480 900663..900923 - 261 WP_001059690.1 hypothetical protein Antitoxin
EFD77_RS04485 901264..901467 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EFD77_RS04490 901464..901700 - 237 WP_000349581.1 hypothetical protein -
EFD77_RS04495 901925..902506 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
EFD77_RS04500 902579..903196 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
EFD77_RS04505 903351..903845 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EFD77_RS04510 904244..904666 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EFD77_RS04515 904814..905530 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(7-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T114778 WP_000052076.1 NZ_CP033982:c900634-900446 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T114778 NZ_CP033982:c900634-900446 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT114778 WP_001059690.1 NZ_CP033982:c900923-900663 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT114778 NZ_CP033982:c900923-900663 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References