Detailed information of TA system TA114759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 4580119..4581074
• Replicon: chromosome
• Accession: NZ_CP033972
• Organism: Gordonia insulae strain MMS17-SY073

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: D7316_RS20895
• Protein ID: WP_124709959.1
• Coordinates: 4580119..4580691 (-)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: D7316_RS20900
• Protein ID: WP_124709960.1
• Coordinates: 4580688..4581074 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7316_RS20880	4575748..4576602	-	855	WP_197718279.1	DUF2236 domain-containing protein	-
D7316_RS20885	4576728..4579055	-	2328	WP_124709957.1	MFS transporter	-
D7316_RS20890	4579228..4580058	+	831	WP_124709958.1	SDR family NAD(P)-dependent oxidoreductase	-
D7316_RS20895	4580119..4580691	-	573	WP_124709959.1	zeta toxin family protein	Toxin
D7316_RS20900	4580688..4581074	-	387	WP_124709960.1	hypothetical protein	Antitoxin
D7316_RS20905	4581157..4581981	-	825	WP_124709961.1	SDR family NAD(P)-dependent oxidoreductase	-
D7316_RS20910	4582281..4583294	-	1014	WP_124709962.1	ferritin-like domain-containing protein	-
D7316_RS20915	4583499..4583966	+	468	WP_124709963.1	MarR family transcriptional regulator	-
D7316_RS20920	4583963..4585201	+	1239	WP_124709964.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-134)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-106)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21000.99 Da
• Isoelectric Point: 8.4813

>T114759 WP_124709959.1 NZ_CP033972:c4580691-4580119 [Gordonia insulae]
VRRLDLVIGPNGAGKSTFVEYTLAPLLPGSVFVNADLIARRRWPEEAEARSYDAARIAAATRERLIDDGRSFIAETVFSH
ESKLELIDRAHAAGYFVVLHVLLVPEALAVLRVAYRQSAGGHSVPEHKIRARYRRLWPLAADAVHRTDEATVYNTALDRA
PTIVAEFTQGVLVGAARWPEWAPGELVRLG

Nucleotide

• Length: 573 bp

>T114759 NZ_CP033972:c4580691-4580119 [Gordonia insulae]
GTGAGGCGCCTGGATCTGGTGATCGGCCCGAACGGCGCCGGAAAGTCGACGTTCGTCGAGTACACCCTCGCTCCCCTGTT
GCCGGGGAGCGTCTTCGTCAACGCGGACCTCATCGCGCGCCGACGCTGGCCCGAGGAGGCCGAGGCACGCTCCTACGATG
CCGCGCGAATCGCCGCGGCGACGCGGGAACGGTTGATCGACGACGGGCGCTCGTTCATCGCCGAGACCGTGTTCTCGCAT
GAATCAAAGCTCGAGCTGATCGACCGAGCACATGCAGCCGGGTACTTTGTCGTGCTCCACGTCCTGCTCGTCCCCGAGGC
TCTTGCGGTCCTGCGAGTCGCCTACCGACAATCGGCGGGCGGGCATTCGGTGCCAGAGCACAAGATCCGCGCCCGCTACC
GGCGGCTCTGGCCGCTCGCCGCCGATGCCGTTCACCGGACCGACGAGGCGACGGTCTACAACACCGCGCTCGACCGGGCT
CCCACCATCGTCGCCGAGTTCACCCAAGGGGTGCTCGTCGGAGCCGCCAGGTGGCCCGAGTGGGCGCCTGGCGAACTCGT
GAGGCTCGGATGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13935.36 Da
• Isoelectric Point: 5.2566

>AT114759 WP_124709960.1 NZ_CP033972:c4581074-4580688 [Gordonia insulae]
MTRAADKVTRVDADLVDSAIAEGRRQQRTGRQQLEYWARVGRALTTHESASLRRVQAALSGAIPTTDLGGDEGRAFNAQI
RARVSEDLATADYRRELSASGVTTVSLDEAGRIVEHLPDGTTRVLDDE

Nucleotide

• Length: 387 bp

>AT114759 NZ_CP033972:c4581074-4580688 [Gordonia insulae]
ATGACCAGAGCCGCGGACAAGGTCACCCGCGTCGACGCCGACCTCGTCGACAGCGCGATCGCCGAAGGCCGTCGTCAACA
GCGAACCGGACGACAGCAACTCGAGTACTGGGCGCGCGTCGGCCGCGCACTCACCACCCACGAGTCCGCGTCACTGAGGC
GCGTCCAGGCCGCGCTGTCGGGAGCCATACCGACAACCGACCTCGGGGGCGACGAAGGCCGCGCGTTCAACGCCCAGATC
CGCGCCCGGGTGAGCGAGGATCTGGCCACGGCGGACTACCGACGCGAACTCTCCGCGAGTGGAGTCACCACCGTGTCGCT
CGATGAGGCCGGCCGGATCGTCGAACACCTGCCGGACGGGACCACCCGAGTCCTCGACGACGAGTGA