114758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4092926..4093551 Replicon chromosome
Accession NZ_CP033972
Organism Gordonia insulae strain MMS17-SY073

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D7316_RS18565 Protein ID WP_124709569.1
Coordinates 4093138..4093551 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D7316_RS18560 Protein ID WP_124709568.1
Coordinates 4092926..4093147 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7316_RS18530 4088383..4089807 + 1425 WP_124709563.1 aldehyde dehydrogenase family protein -
D7316_RS18535 4089876..4090202 + 327 WP_124711432.1 DUF202 domain-containing protein -
D7316_RS18540 4090199..4090510 + 312 WP_197718263.1 DUF202 domain-containing protein -
D7316_RS18545 4090731..4091129 - 399 WP_124709565.1 hypothetical protein -
D7316_RS18550 4091606..4091980 + 375 WP_124709566.1 hypothetical protein -
D7316_RS18555 4092027..4092779 + 753 WP_164473816.1 SGNH/GDSL hydrolase family protein -
D7316_RS18560 4092926..4093147 + 222 WP_124709568.1 ribbon-helix-helix protein, CopG family Antitoxin
D7316_RS18565 4093138..4093551 + 414 WP_124709569.1 PIN domain nuclease Toxin
D7316_RS18570 4093557..4094522 - 966 WP_124709570.1 alpha/beta hydrolase -
D7316_RS18575 4094527..4095597 - 1071 WP_124709571.1 HNH endonuclease -
D7316_RS18580 4095610..4096035 - 426 WP_124709572.1 hypothetical protein -
D7316_RS18585 4096148..4096354 + 207 WP_124709573.1 hypothetical protein -
D7316_RS18590 4096753..4098006 - 1254 WP_124709574.1 hypothetical protein -
D7316_RS18595 4098007..4098330 - 324 WP_164473817.1 WXG100 family type VII secretion target -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14885.01 Da        Isoelectric Point: 6.2158

>T114758 WP_124709569.1 NZ_CP033972:4093138-4093551 [Gordonia insulae]
VAVTNSWLIDKSALVRLAGSPDAREWALRIERGLVCIATMTRLEVGYSARNAHDARTALRSSPLSAMPVEYVTPAIEDRA
LEVQLQLAEQGHHRAPSIPDLMIAATAELAGHCVLHVDKDFEHIAGVTGQPIERLST

Download         Length: 414 bp

>T114758 NZ_CP033972:4093138-4093551 [Gordonia insulae]
GTGGCAGTGACGAACTCGTGGCTGATCGATAAGTCGGCACTGGTTCGTCTTGCCGGCAGTCCGGACGCCCGTGAGTGGGC
GCTACGAATTGAACGGGGGCTTGTCTGCATCGCGACGATGACCCGACTCGAGGTTGGCTACTCAGCCAGGAATGCGCACG
ATGCACGGACAGCTCTGCGGAGCTCCCCGCTATCGGCGATGCCCGTGGAATACGTCACGCCAGCGATCGAAGATAGAGCG
CTAGAGGTCCAACTCCAGTTGGCCGAGCAGGGACACCATCGCGCGCCCTCGATACCAGACTTGATGATCGCGGCCACCGC
AGAATTGGCCGGTCATTGTGTCCTGCACGTAGACAAGGATTTTGAGCATATTGCCGGGGTGACCGGCCAGCCCATCGAAC
GATTGTCGACGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7917.85 Da        Isoelectric Point: 4.3917

>AT114758 WP_124709568.1 NZ_CP033972:4092926-4093147 [Gordonia insulae]
VSDILIRGVPDDVVAAIDARAARLGLSRTQYLRRRLALDAGAESTSVTVEDLQSFADTFSALADDHLMSQAWQ

Download         Length: 222 bp

>AT114758 NZ_CP033972:4092926-4093147 [Gordonia insulae]
GTGAGCGATATCCTGATTCGAGGCGTCCCCGATGACGTGGTGGCCGCAATCGATGCGCGCGCCGCGCGGTTGGGTCTTTC
GCGGACCCAGTACCTGCGCCGTCGGCTTGCTCTCGATGCTGGTGCCGAGTCGACCTCCGTGACCGTCGAAGACCTGCAGT
CGTTTGCCGACACGTTCTCCGCGCTCGCCGACGATCACCTGATGTCGCAAGCGTGGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References