Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 249670..250238 Replicon plasmid unnamed2
Accession NZ_CP033971
Organism Cupriavidus pauculus strain FDAARGOS_614

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EHF44_RS27810 Protein ID WP_124686988.1
Coordinates 249670..250044 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EHF44_RS27815 Protein ID WP_124686989.1
Coordinates 250041..250238 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF44_RS27780 244970..245155 - 186 WP_124686983.1 hypothetical protein -
EHF44_RS27785 245152..245418 - 267 WP_124686984.1 hypothetical protein -
EHF44_RS27790 245747..247510 - 1764 WP_124686985.1 SIR2 family protein -
EHF44_RS27795 247593..248435 - 843 WP_124686986.1 cell envelope biogenesis protein TolA -
EHF44_RS27805 248948..249157 - 210 WP_124686987.1 HEAT repeat domain-containing protein -
EHF44_RS27810 249670..250044 - 375 WP_124686988.1 type II toxin-antitoxin system VapC family toxin Toxin
EHF44_RS27815 250041..250238 - 198 WP_124686989.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EHF44_RS27820 250512..250662 + 151 Protein_232 transposase -
EHF44_RS27825 251362..252636 - 1275 WP_124687087.1 tail fiber protein -
EHF44_RS27830 252856..253974 + 1119 WP_124686990.1 glycosyltransferase family 2 protein -
EHF44_RS27835 254177..255028 - 852 WP_124686991.1 3-keto-5-aminohexanoate cleavage protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..333965 333965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13630.95 Da        Isoelectric Point: 7.1067

>T114755 WP_124686988.1 NZ_CP033971:c250044-249670 [Cupriavidus pauculus]
MMVLVDTSVWVSHFKRSNTALVALLESDRVLSHPMVLLELTCGTPPEPRSRTLASVGLLQQANQATLAEAMAFVEQERLY
GAGCGLVDVMLLASALLTPQARLWTLDKRLAGLCERFGVEYRSK

Download         Length: 375 bp

>T114755 NZ_CP033971:c250044-249670 [Cupriavidus pauculus]
ATGATGGTGCTGGTTGACACATCGGTGTGGGTCTCCCACTTCAAGCGCAGCAACACGGCGCTCGTCGCCTTGCTGGAGTC
GGATCGTGTCCTGTCGCACCCGATGGTGCTGCTCGAACTCACTTGCGGCACGCCTCCGGAGCCGAGAAGCCGCACGCTGG
CTAGCGTCGGCCTGCTCCAGCAGGCGAACCAGGCCACGCTTGCGGAGGCGATGGCGTTTGTGGAGCAAGAACGGCTATAT
GGCGCCGGATGCGGTCTGGTGGACGTGATGCTGCTCGCTTCGGCCCTGCTGACGCCGCAGGCGCGGCTTTGGACGCTCGA
CAAGCGGTTGGCCGGACTGTGCGAGCGGTTTGGCGTGGAATACCGGTCAAAGTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7294.35 Da        Isoelectric Point: 4.9816

>AT114755 WP_124686989.1 NZ_CP033971:c250238-250041 [Cupriavidus pauculus]
MRTTVTIEDSLYEQALELADTSMDRTDLFREAIKTFVRVQAAKRLAALGGAQPDMQEIPRRAPSL

Download         Length: 198 bp

>AT114755 NZ_CP033971:c250238-250041 [Cupriavidus pauculus]
ATGCGCACTACCGTCACAATAGAAGATTCGCTCTACGAGCAAGCCCTTGAGTTGGCCGACACGTCCATGGACCGGACGGA
CCTGTTTCGGGAGGCCATCAAAACGTTCGTGCGTGTCCAAGCCGCTAAACGGCTGGCCGCACTGGGTGGCGCGCAGCCCG
ACATGCAGGAGATTCCTCGCCGGGCGCCGTCGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References