Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1739664..1740199 Replicon chromosome
Accession NZ_CP033970
Organism Cupriavidus pauculus strain FDAARGOS_614

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EHF44_RS25900 Protein ID WP_124686529.1
Coordinates 1739930..1740199 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag EHF44_RS25895 Protein ID WP_124686782.1
Coordinates 1739664..1739933 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF44_RS25875 1735684..1736463 - 780 WP_124686525.1 AraC family transcriptional regulator -
EHF44_RS25880 1736447..1737355 - 909 WP_124686526.1 DMT family transporter -
EHF44_RS25885 1737478..1738353 - 876 WP_124686527.1 LysR family transcriptional regulator -
EHF44_RS25890 1738448..1739557 + 1110 WP_124686528.1 NADH:flavin oxidoreductase/NADH oxidase -
EHF44_RS25895 1739664..1739933 + 270 WP_124686782.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EHF44_RS25900 1739930..1740199 + 270 WP_124686529.1 Txe/YoeB family addiction module toxin Toxin
EHF44_RS25905 1740214..1741389 - 1176 WP_124686530.1 L-rhamnonate dehydratase -
EHF44_RS25910 1741416..1742441 - 1026 WP_124686531.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
EHF44_RS25915 1742462..1743427 - 966 WP_124686532.1 tripartite tricarboxylate transporter substrate binding protein -
EHF44_RS25920 1743695..1744615 + 921 WP_124686533.1 dihydrodipicolinate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10436.82 Da        Isoelectric Point: 9.8741

>T114754 WP_124686529.1 NZ_CP033970:1739930-1740199 [Cupriavidus pauculus]
MTRNILFTADAWAQYLFWQGQDRKTLKRINQLVEDARRSPFEGIGKPEPLKGNLTGFWSRRIDDTNRLVYKADDVAVSIV
SCRYHYGDR

Download         Length: 270 bp

>T114754 NZ_CP033970:1739930-1740199 [Cupriavidus pauculus]
ATGACGCGCAACATCCTGTTCACCGCGGATGCGTGGGCGCAATACCTGTTCTGGCAGGGGCAGGACCGGAAGACCCTGAA
GCGCATCAACCAGCTTGTCGAGGATGCGCGGCGGTCCCCGTTCGAGGGAATCGGCAAGCCGGAGCCGCTGAAGGGCAACC
TGACCGGCTTCTGGTCGCGCCGCATCGACGATACCAATCGGCTGGTCTACAAGGCCGACGACGTGGCCGTCTCGATCGTT
AGCTGCCGCTACCACTACGGCGACCGCTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9887.01 Da        Isoelectric Point: 5.0346

>AT114754 WP_124686782.1 NZ_CP033970:1739664-1739933 [Cupriavidus pauculus]
MRTVHFSDARNNLKGVIDQAIDDHEAVLITRRDAPNAVIMSQAQYDSWAETIYLLNSPANAAHLSRSLEQLRAGEAKART
LLDPDTPTE

Download         Length: 270 bp

>AT114754 NZ_CP033970:1739664-1739933 [Cupriavidus pauculus]
ATGCGCACCGTCCACTTCTCGGATGCCCGCAACAACCTCAAGGGCGTGATCGACCAGGCCATCGATGACCACGAGGCGGT
TCTGATCACGCGCCGCGACGCGCCCAACGCGGTAATCATGTCGCAGGCCCAGTACGATAGCTGGGCCGAAACCATCTACC
TGCTCAATTCCCCTGCCAACGCCGCCCATCTGTCGCGTTCGCTCGAACAGTTGCGCGCCGGCGAGGCCAAAGCGCGCACC
CTTCTGGACCCCGATACCCCGACCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References