Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 97309..98988 Replicon chromosome
Accession NZ_CP033970
Organism Cupriavidus pauculus strain FDAARGOS_614

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EHF44_RS18605 Protein ID WP_172966130.1
Coordinates 97309..98631 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EHF44_RS18610 Protein ID WP_124685227.1
Coordinates 98632..98988 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF44_RS18590 92795..95230 + 2436 WP_124685224.1 TonB-dependent receptor -
EHF44_RS18595 95250..95978 + 729 WP_124685225.1 DUF4198 domain-containing protein -
EHF44_RS18600 96148..96939 - 792 WP_124685226.1 alpha/beta hydrolase -
EHF44_RS28405 96958..97128 - 171 WP_172966129.1 hypothetical protein -
EHF44_RS18605 97309..98631 - 1323 WP_172966130.1 type II toxin-antitoxin system HipA family toxin Toxin
EHF44_RS18610 98632..98988 - 357 WP_124685227.1 helix-turn-helix domain-containing protein Antitoxin
EHF44_RS18615 99251..99985 + 735 WP_124686665.1 IclR family transcriptional regulator -
EHF44_RS18620 100007..100702 - 696 WP_124685228.1 4'-phosphopantetheinyl transferase superfamily protein -
EHF44_RS18625 100745..101191 - 447 WP_124685229.1 excinuclease ATPase subunit -
EHF44_RS18630 101280..102509 - 1230 WP_124685230.1 beta-ketoacyl-ACP synthase -
EHF44_RS18635 102506..103237 - 732 WP_124685231.1 3-oxoacyl-ACP reductase FabG -
EHF44_RS18640 103234..103713 - 480 WP_124685232.1 hotdog family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48196.04 Da        Isoelectric Point: 8.4855

>T114753 WP_172966130.1 NZ_CP033970:c98631-97309 [Cupriavidus pauculus]
MGRRALRRRLGVWMNGWLTGIWEHGPDGESFAYDADWMASSQGRPLSLSLPFRSDVLPYRGRVVTAYFDNLLPDSDAIRR
RLAQRHRTQGTGPFALLAALGRDCVGALQLLPADAAPEHLRSIDGTPLDEAAIARLLRDATRSVPMGQHDDDSDLRLSIA
GAQEKTALLYHEGRWLLPHGSTPTTHILKLPLGLVGNMRADMRTSVENEWLCARLVRHFGLAVADCAIATFEDQKVLAVT
RFDRRLAPDGSWIIRLPQEDFCQALGLSPLSKYQADGGPGIADIMAVLAGSETPGHDRRQFFTAQILFWLLAATDGHAKN
FSLSIGPGGRYWSTPLYDVLSAYPIMGSGANQLAPQKARLAMAVRGSQNHYRVAQILRRHWLEQGRRVGLPADEVEAILA
GLKDAVAPAIDATASELPAGFPADVAERVFAGLRAQARRI

Download         Length: 1323 bp

>T114753 NZ_CP033970:c98631-97309 [Cupriavidus pauculus]
ATGGGTCGACGCGCGCTGCGGCGCCGGCTGGGCGTGTGGATGAACGGCTGGCTGACCGGCATCTGGGAGCATGGCCCGGA
CGGCGAGTCCTTCGCCTACGACGCCGACTGGATGGCCAGCAGCCAGGGCCGGCCGCTATCGCTGTCGCTGCCGTTCCGCT
CCGACGTGCTGCCGTACCGTGGCCGGGTGGTGACCGCCTATTTCGACAACCTGCTGCCCGACAGCGACGCCATCCGCCGC
CGGCTGGCCCAGCGGCACCGCACGCAGGGCACGGGGCCGTTCGCGCTGCTGGCCGCGCTGGGCCGCGATTGCGTCGGCGC
GCTGCAACTGCTGCCGGCCGATGCGGCGCCCGAGCACCTGCGCAGCATCGACGGCACGCCGCTGGACGAAGCCGCCATCG
CTCGGCTGCTGCGCGACGCCACGCGAAGTGTGCCGATGGGCCAGCACGACGACGACAGCGACCTGCGCCTGTCGATCGCC
GGCGCGCAGGAAAAGACCGCGCTGCTGTATCACGAAGGCCGCTGGCTGCTGCCCCACGGCAGCACGCCAACCACGCACAT
CCTCAAGCTGCCGCTGGGGCTGGTGGGCAACATGCGGGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCGCGC
GGCTGGTGCGGCATTTCGGGCTGGCGGTGGCCGATTGCGCCATCGCCACGTTCGAGGACCAGAAGGTGCTGGCCGTGACG
CGCTTCGACCGCCGGCTGGCACCCGATGGGAGCTGGATCATCCGCCTGCCGCAGGAGGATTTCTGCCAGGCGCTGGGCCT
GTCGCCGTTGTCGAAGTACCAGGCCGACGGCGGGCCGGGCATCGCCGACATCATGGCGGTGCTGGCCGGGTCCGAGACGC
CGGGCCATGACCGGCGGCAGTTCTTCACCGCGCAGATCCTGTTCTGGCTGCTGGCCGCCACGGACGGCCATGCCAAGAAC
TTCAGCCTGTCGATCGGGCCCGGCGGCCGCTACTGGTCCACGCCGCTCTACGACGTGCTCTCCGCGTATCCGATCATGGG
CAGCGGCGCCAACCAGTTGGCTCCGCAGAAGGCGCGGCTGGCCATGGCGGTACGCGGCAGCCAGAACCACTATCGCGTGG
CGCAGATCCTGCGCCGGCACTGGCTGGAGCAGGGGCGCCGGGTGGGGCTGCCCGCCGACGAGGTCGAGGCCATCCTGGCC
GGCCTGAAGGACGCCGTGGCGCCGGCCATCGACGCCACGGCCAGCGAACTGCCCGCCGGCTTTCCCGCCGACGTGGCCGA
GCGCGTCTTTGCCGGGCTGCGCGCGCAGGCCCGGCGCATCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12471.39 Da        Isoelectric Point: 11.9242

>AT114753 WP_124685227.1 NZ_CP033970:c98988-98632 [Cupriavidus pauculus]
MSTTYPIRILSQLSPVLQGFRKARGLTQAELAARLGVSQQSYARLEANPGRASMARVLAALQALEVDLALTPRGQLDAGT
AAKASKAPKANAPKTPPAAKTARPARSRKPRTAPGEDW

Download         Length: 357 bp

>AT114753 NZ_CP033970:c98988-98632 [Cupriavidus pauculus]
ATGTCCACGACCTACCCGATCCGCATCCTGAGCCAGCTCAGCCCCGTGCTGCAGGGGTTTCGCAAGGCGCGCGGCCTGAC
CCAGGCCGAACTGGCCGCGCGGCTGGGCGTCAGCCAGCAGAGCTACGCGCGGCTGGAAGCCAATCCCGGCCGGGCCAGCA
TGGCACGCGTGCTGGCGGCGCTGCAGGCACTGGAGGTGGACCTGGCCCTGACGCCGCGCGGCCAGCTCGATGCCGGGACG
GCGGCCAAGGCGTCGAAAGCCCCGAAAGCCAACGCCCCGAAAACCCCGCCCGCCGCCAAGACAGCCAGGCCGGCCCGTTC
GCGCAAGCCCCGGACGGCGCCGGGGGAGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References