Detailed information of TA system TA114746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-DnaT
• Location: 3850457..3851023
• Replicon: chromosome
• Accession: NZ_CP033966
• Organism: Pigmentiphaga sp. H8

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: EGT29_RS18195
• Protein ID: WP_124690298.1
• Coordinates: 3850457..3850771 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGT29_RS18200
• Protein ID: WP_124690299.1
• Coordinates: 3850772..3851023 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGT29_RS18180	3845951..3846904	+	954	WP_124692424.1	bifunctional riboflavin kinase/FAD synthetase	-
EGT29_RS18185	3847141..3849957	+	2817	WP_124690296.1	isoleucine--tRNA ligase	-
EGT29_RS18190	3849957..3850448	+	492	WP_124690297.1	lipoprotein signal peptidase	-
EGT29_RS18195	3850457..3850771	-	315	WP_124690298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGT29_RS18200	3850772..3851023	-	252	WP_124690299.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EGT29_RS18205	3851203..3852393	+	1191	WP_124690300.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
EGT29_RS18210	3852414..3852971	+	558	WP_124690301.1	hypothetical protein	-
EGT29_RS18215	3852968..3853417	+	450	WP_124690302.1	dUTP diphosphatase	-
EGT29_RS18220	3853428..3854144	+	717	WP_124690303.1	GntR family transcriptional regulator	-
EGT29_RS18225	3854158..3854904	-	747	WP_124690304.1	SDR family oxidoreductase	-
EGT29_RS18230	3854909..3855883	-	975	WP_124690305.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-65)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11782.74 Da
• Isoelectric Point: 9.7098

>T114746 WP_124690298.1 NZ_CP033966:c3850771-3850457 [Pigmentiphaga sp. H8]
MSYKLFFLPEARQEWDGLDGSLKTQFKAALKKRLETPRLPGSQLRSPLVDCYKIKLRGVGYRLVYLVRDEAIPPDIVVLV
VGRRDGGIYEAAAEMLESGRNVDK

Nucleotide

• Length: 315 bp

>T114746 NZ_CP033966:c3850771-3850457 [Pigmentiphaga sp. H8]
ATGTCGTACAAACTATTCTTCCTGCCTGAGGCTCGGCAAGAGTGGGATGGGTTGGATGGTTCGCTCAAGACCCAGTTCAA
AGCCGCGTTAAAAAAGCGGCTGGAGACTCCACGGCTACCAGGCTCACAGCTTCGCTCGCCCTTGGTCGATTGCTACAAGA
TCAAGCTACGCGGCGTCGGCTACAGATTGGTCTATTTGGTGCGGGACGAGGCGATCCCACCAGACATTGTCGTTCTGGTC
GTAGGGCGCCGAGATGGTGGGATCTACGAAGCTGCGGCCGAAATGCTGGAGTCAGGCCGCAACGTGGACAAATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9374.67 Da
• Isoelectric Point: 4.6211

>AT114746 WP_124690299.1 NZ_CP033966:c3851023-3850772 [Pigmentiphaga sp. H8]
MEEIHSLLSVSISEFKQNPGKVVEEAHGQPVAVLNHNRPAFYTVSPELMAKMAELYDERQLEPLVRSRLKSLDQAVEVSL
DDL

Nucleotide

• Length: 252 bp

>AT114746 NZ_CP033966:c3851023-3850772 [Pigmentiphaga sp. H8]
ATGGAAGAGATCCATAGCTTGCTGAGCGTCAGCATCTCCGAGTTCAAGCAGAACCCTGGCAAGGTGGTCGAGGAGGCCCA
TGGACAGCCGGTGGCCGTGCTCAACCACAACCGCCCTGCCTTCTACACCGTCTCCCCAGAGCTCATGGCGAAAATGGCCG
AGTTGTACGACGAACGCCAACTCGAACCCTTGGTGCGCTCGCGCCTGAAATCCCTCGACCAGGCTGTCGAAGTCAGCCTC
GACGACCTGTAA