Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3471571..3472239 Replicon chromosome
Accession NZ_CP033966
Organism Pigmentiphaga sp. H8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EGT29_RS16410 Protein ID WP_124689986.1
Coordinates 3472063..3472239 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EGT29_RS16405 Protein ID WP_124689985.1
Coordinates 3471571..3471984 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT29_RS16380 3467377..3467919 + 543 WP_124692392.1 biofilm regulation protein kinase SiaB -
EGT29_RS16385 3467938..3468315 + 378 WP_124689982.1 biofilm regulation phosphoprotein SiaC -
EGT29_RS16390 3468327..3469115 + 789 WP_124689983.1 biofilm regulation diguanylate cyclase SiaD -
EGT29_RS16395 3469253..3471274 + 2022 WP_124689984.1 FUSC family protein -
EGT29_RS16405 3471571..3471984 - 414 WP_124689985.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGT29_RS16410 3472063..3472239 - 177 WP_124689986.1 type II toxin-antitoxin system HicA family toxin Toxin
EGT29_RS16420 3472609..3473544 - 936 WP_124689987.1 3-keto-5-aminohexanoate cleavage protein -
EGT29_RS16425 3473566..3474435 - 870 WP_124689988.1 fumarylacetoacetate hydrolase family protein -
EGT29_RS16430 3474447..3475382 - 936 WP_124689989.1 VOC family protein -
EGT29_RS16435 3475392..3476372 - 981 WP_124689990.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6535.57 Da        Isoelectric Point: 10.9585

>T114745 WP_124689986.1 NZ_CP033966:c3472239-3472063 [Pigmentiphaga sp. H8]
VKVNEFRRWLAAQGATFKEGAGHTKVYYQGKQTTLPRHPSQELGEGLRKAILKQLGIK

Download         Length: 177 bp

>T114745 NZ_CP033966:c3472239-3472063 [Pigmentiphaga sp. H8]
GTGAAAGTTAACGAGTTCCGGCGATGGTTAGCTGCCCAGGGCGCCACATTCAAGGAAGGCGCCGGTCACACAAAGGTGTA
CTACCAGGGCAAGCAGACCACTCTGCCAAGGCACCCAAGCCAGGAGCTTGGGGAAGGGCTGAGAAAGGCGATTCTCAAGC
AACTGGGGATCAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15080.36 Da        Isoelectric Point: 5.0019

>AT114745 WP_124689985.1 NZ_CP033966:c3471984-3471571 [Pigmentiphaga sp. H8]
MRYAARIEPDGNVFMVSFRDIPEALTAADTREEAEAAAADALRTAMDFYFEDRRAVPLPSKAQAGEVLVELPASLWAKVL
LLNEMVRQDVAPVELARRLGTRKQEVTRIMDLGHATKIDTIAAALASLGRELSLSVR

Download         Length: 414 bp

>AT114745 NZ_CP033966:c3471984-3471571 [Pigmentiphaga sp. H8]
ATGCGCTACGCCGCTCGAATCGAACCGGATGGCAACGTTTTCATGGTGTCGTTCCGCGACATCCCCGAAGCTCTGACGGC
TGCGGATACCCGCGAGGAAGCCGAGGCCGCAGCGGCCGATGCATTGCGCACGGCCATGGACTTCTATTTCGAGGATCGAC
GGGCCGTACCCCTGCCGTCCAAGGCCCAGGCCGGTGAGGTCCTGGTTGAACTACCTGCCAGCCTGTGGGCAAAGGTCCTG
CTGCTCAACGAAATGGTCCGCCAGGACGTGGCGCCGGTGGAACTGGCGCGCCGGCTGGGAACGCGCAAGCAGGAAGTCAC
CCGCATCATGGACCTGGGCCATGCCACCAAGATCGATACCATTGCTGCCGCGCTTGCCAGCCTAGGGCGAGAGCTGAGCT
TGTCGGTGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References