Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1249700..1250289 Replicon chromosome
Accession NZ_CP033966
Organism Pigmentiphaga sp. H8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EGT29_RS05915 Protein ID WP_124688146.1
Coordinates 1249700..1249954 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EGT29_RS05920 Protein ID WP_124688147.1
Coordinates 1249951..1250289 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT29_RS05890 1244927..1247668 - 2742 WP_124688144.1 bifunctional acetate--CoA ligase family protein/GNAT family N-acetyltransferase -
EGT29_RS05895 1247815..1249242 + 1428 WP_124688145.1 glutamate--tRNA ligase -
EGT29_RS05915 1249700..1249954 + 255 WP_124688146.1 type II toxin-antitoxin system HicA family toxin Toxin
EGT29_RS05920 1249951..1250289 + 339 WP_124688147.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGT29_RS28640 1250847..1251293 - 447 WP_202865591.1 zinc ribbon domain-containing protein -
EGT29_RS05945 1251290..1251616 - 327 WP_124688148.1 hypothetical protein -
EGT29_RS05950 1251905..1252498 + 594 WP_124688149.1 YdeI/OmpD-associated family protein -
EGT29_RS05955 1252819..1253262 + 444 WP_124688150.1 hypothetical protein -
EGT29_RS05960 1253479..1254510 + 1032 WP_124688151.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-78)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9413.93 Da        Isoelectric Point: 10.4777

>T114744 WP_124688146.1 NZ_CP033966:1249700-1249954 [Pigmentiphaga sp. H8]
MKAKHQRTLELIFSRPTPGGVKWSAIVGLFHELGAEFVEREGSRVAVVFRDQVMVLHRPHPTPDVDKGAVASIRKWLEES
GVKP

Download         Length: 255 bp

>T114744 NZ_CP033966:1249700-1249954 [Pigmentiphaga sp. H8]
ATGAAAGCCAAGCATCAGCGCACGCTGGAACTGATCTTCTCCCGTCCGACCCCAGGCGGAGTGAAGTGGTCGGCCATAGT
GGGGCTGTTTCATGAGCTTGGAGCGGAGTTTGTCGAACGAGAGGGATCCCGGGTCGCAGTCGTTTTTCGGGATCAGGTAA
TGGTCCTACATCGCCCTCATCCGACTCCCGACGTAGACAAAGGCGCTGTTGCTTCTATCCGCAAATGGCTCGAAGAATCA
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12315.94 Da        Isoelectric Point: 5.1716

>AT114744 WP_124688147.1 NZ_CP033966:1249951-1250289 [Pigmentiphaga sp. H8]
MKNVMNIDGYQAVIQFDPEIQMFRGEFVGLNGGADFYASDVPGLVREGKASLKVFLDICEERGIEPRKHFSGKFNLRVSS
KVHEAASIAAAAEGESLNQWIAKTIEEAVSTH

Download         Length: 339 bp

>AT114744 NZ_CP033966:1249951-1250289 [Pigmentiphaga sp. H8]
ATGAAGAATGTGATGAACATCGACGGCTATCAAGCAGTTATCCAATTTGACCCGGAAATCCAGATGTTCCGGGGAGAGTT
CGTCGGACTCAATGGTGGGGCCGACTTCTACGCGTCGGATGTTCCCGGCCTCGTTCGCGAAGGGAAGGCATCGCTCAAGG
TCTTTCTCGATATATGTGAGGAGCGTGGCATTGAGCCGCGCAAGCACTTTTCAGGGAAGTTCAATCTGCGTGTTTCCTCG
AAGGTACACGAAGCCGCGAGCATTGCCGCGGCGGCGGAAGGCGAAAGCCTCAATCAATGGATTGCGAAGACCATTGAAGA
GGCGGTGTCCACGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References