Detailed information of TA system TA114744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1249700..1250289
• Replicon: chromosome
• Accession: NZ_CP033966
• Organism: Pigmentiphaga sp. H8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EGT29_RS05915
• Protein ID: WP_124688146.1
• Coordinates: 1249700..1249954 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EGT29_RS05920
• Protein ID: WP_124688147.1
• Coordinates: 1249951..1250289 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGT29_RS05890	1244927..1247668	-	2742	WP_124688144.1	bifunctional acetate--CoA ligase family protein/GNAT family N-acetyltransferase	-
EGT29_RS05895	1247815..1249242	+	1428	WP_124688145.1	glutamate--tRNA ligase	-
EGT29_RS05915	1249700..1249954	+	255	WP_124688146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGT29_RS05920	1249951..1250289	+	339	WP_124688147.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGT29_RS28640	1250847..1251293	-	447	WP_202865591.1	zinc ribbon domain-containing protein	-
EGT29_RS05945	1251290..1251616	-	327	WP_124688148.1	hypothetical protein	-
EGT29_RS05950	1251905..1252498	+	594	WP_124688149.1	YdeI/OmpD-associated family protein	-
EGT29_RS05955	1252819..1253262	+	444	WP_124688150.1	hypothetical protein	-
EGT29_RS05960	1253479..1254510	+	1032	WP_124688151.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-78)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9413.93 Da
• Isoelectric Point: 10.4777

>T114744 WP_124688146.1 NZ_CP033966:1249700-1249954 [Pigmentiphaga sp. H8]
MKAKHQRTLELIFSRPTPGGVKWSAIVGLFHELGAEFVEREGSRVAVVFRDQVMVLHRPHPTPDVDKGAVASIRKWLEES
GVKP

Nucleotide

• Length: 255 bp

>T114744 NZ_CP033966:1249700-1249954 [Pigmentiphaga sp. H8]
ATGAAAGCCAAGCATCAGCGCACGCTGGAACTGATCTTCTCCCGTCCGACCCCAGGCGGAGTGAAGTGGTCGGCCATAGT
GGGGCTGTTTCATGAGCTTGGAGCGGAGTTTGTCGAACGAGAGGGATCCCGGGTCGCAGTCGTTTTTCGGGATCAGGTAA
TGGTCCTACATCGCCCTCATCCGACTCCCGACGTAGACAAAGGCGCTGTTGCTTCTATCCGCAAATGGCTCGAAGAATCA
GGAGTCAAGCCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12315.94 Da
• Isoelectric Point: 5.1716

>AT114744 WP_124688147.1 NZ_CP033966:1249951-1250289 [Pigmentiphaga sp. H8]
MKNVMNIDGYQAVIQFDPEIQMFRGEFVGLNGGADFYASDVPGLVREGKASLKVFLDICEERGIEPRKHFSGKFNLRVSS
KVHEAASIAAAAEGESLNQWIAKTIEEAVSTH

Nucleotide

• Length: 339 bp

>AT114744 NZ_CP033966:1249951-1250289 [Pigmentiphaga sp. H8]
ATGAAGAATGTGATGAACATCGACGGCTATCAAGCAGTTATCCAATTTGACCCGGAAATCCAGATGTTCCGGGGAGAGTT
CGTCGGACTCAATGGTGGGGCCGACTTCTACGCGTCGGATGTTCCCGGCCTCGTTCGCGAAGGGAAGGCATCGCTCAAGG
TCTTTCTCGATATATGTGAGGAGCGTGGCATTGAGCCGCGCAAGCACTTTTCAGGGAAGTTCAATCTGCGTGTTTCCTCG
AAGGTACACGAAGCCGCGAGCATTGCCGCGGCGGCGGAAGGCGAAAGCCTCAATCAATGGATTGCGAAGACCATTGAAGA
GGCGGTGTCCACGCATTGA