Detailed information of TA system TA114742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 784240..784790
• Replicon: chromosome
• Accession: NZ_CP033966
• Organism: Pigmentiphaga sp. H8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EGT29_RS03845
• Protein ID: WP_202865621.1
• Coordinates: 784509..784790 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGT29_RS03840
• Protein ID: WP_124687775.1
• Coordinates: 784240..784512 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGT29_RS03820	780200..780478	-	279	WP_124687771.1	muconolactone Delta-isomerase	-
EGT29_RS03825	780502..781626	-	1125	WP_124687772.1	muconate/chloromuconate family cycloisomerase	-
EGT29_RS03830	781725..782636	+	912	WP_124687773.1	LysR family transcriptional regulator	-
EGT29_RS03835	782633..783403	-	771	WP_124687774.1	phytanoyl-CoA dioxygenase family protein	-
EGT29_RS03840	784240..784512	+	273	WP_124687775.1	CopG family ribbon-helix-helix protein	Antitoxin
EGT29_RS03845	784509..784790	+	282	WP_202865621.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGT29_RS03850	784929..785156	+	228	WP_124692206.1	transcriptional regulator	-
EGT29_RS03855	785468..788236	+	2769	WP_124687777.1	CRISPR-associated helicase Cas3'	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	783484..795430	11946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10670.31 Da
• Isoelectric Point: 8.4941

>T114742 WP_202865621.1 NZ_CP033966:784509-784790 [Pigmentiphaga sp. H8]
VIWTPLALDDVQNLYRFLAQKDISAARRAVQAIRVGVRMLAKQPRVGRPIEDMDAEFREWLIDFGDSGYVVLYRLHGETA
SILAVRHQKEVGY

Nucleotide

• Length: 282 bp

>T114742 NZ_CP033966:784509-784790 [Pigmentiphaga sp. H8]
GTGATATGGACGCCACTGGCACTGGACGATGTGCAGAACCTCTATCGCTTTCTCGCGCAGAAGGATATAAGCGCCGCGCG
ACGTGCCGTACAAGCAATCCGCGTCGGGGTGAGGATGCTTGCCAAGCAGCCGCGCGTCGGTCGTCCGATCGAAGACATGG
ACGCGGAGTTTCGTGAATGGCTTATCGATTTCGGGGATAGCGGCTATGTTGTCCTATATCGATTGCATGGCGAAACCGCT
TCCATTTTGGCTGTGCGCCATCAAAAAGAAGTAGGGTATTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10547.78 Da
• Isoelectric Point: 5.2063

>AT114742 WP_124687775.1 NZ_CP033966:784240-784512 [Pigmentiphaga sp. H8]
MATTIKLNDDLKARIHRLADQRDRSAHWIMREAITQYVEREEKREAFKQDAMRAWNDYQANGLHVTLEEADAWLAKLEAG
EDAEPPKCHE

Nucleotide

• Length: 273 bp

>AT114742 NZ_CP033966:784240-784512 [Pigmentiphaga sp. H8]
ATGGCTACGACCATCAAGCTCAATGACGACTTGAAAGCTCGCATACATCGCCTTGCAGATCAGCGGGACCGTTCGGCCCA
CTGGATCATGCGCGAAGCAATCACGCAATACGTGGAGCGCGAAGAAAAGCGCGAGGCGTTCAAGCAGGATGCGATGCGTG
CATGGAATGACTATCAGGCCAACGGATTGCACGTGACGCTTGAAGAAGCGGATGCCTGGCTGGCGAAGCTCGAAGCGGGC
GAGGATGCGGAGCCACCTAAGTGCCACGAGTGA