Detailed information of TA system TA114741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 759565..760424
• Replicon: chromosome
• Accession: NZ_CP033966
• Organism: Pigmentiphaga sp. H8

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: EGT29_RS03705
• Protein ID: WP_124687750.1
• Coordinates: 760026..760424 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: EGT29_RS03700
• Protein ID: WP_124687749.1
• Coordinates: 759565..760029 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGT29_RS03685	755162..756595	+	1434	WP_124687746.1	sodium:solute symporter family protein	-
EGT29_RS03690	756742..757581	+	840	WP_124687747.1	ferritin-like domain-containing protein	-
EGT29_RS03695	757623..759077	-	1455	WP_124687748.1	DegQ family serine endoprotease	-
EGT29_RS03700	759565..760029	+	465	WP_124687749.1	helix-turn-helix domain-containing protein	Antitoxin
EGT29_RS03705	760026..760424	+	399	WP_124687750.1	hypothetical protein	Toxin
EGT29_RS03710	760429..761751	-	1323	WP_124687751.1	sensor histidine kinase N-terminal domain-containing protein	-
EGT29_RS03715	761748..762407	-	660	WP_124687752.1	response regulator	-
EGT29_RS03720	762523..763002	+	480	WP_124687753.1	D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase	-
EGT29_RS03725	763009..763869	-	861	WP_124687754.1	SPOR domain-containing protein	-
EGT29_RS03730	763885..764748	-	864	WP_124687755.1	type III pantothenate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SinI-like, DNA-binding domain (83-129)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15366.69 Da
• Isoelectric Point: 8.0518

>T114741 WP_124687750.1 NZ_CP033966:760026-760424 [Pigmentiphaga sp. H8]
MRHSPFTVIYDACVLYPAPLRDFLMWLGLSGRFRARWSREIHEEWKRNLLLNRQDLTRAQLDRTSDLMDRAIPDEFIDNL
FDLDAAAVVSAAQRQRAQLVHPSIDVDRYLDILLRQGLVQTAKALATYRGIL

Nucleotide

• Length: 399 bp

>T114741 NZ_CP033966:760026-760424 [Pigmentiphaga sp. H8]
ATGAGGCATTCCCCCTTCACGGTCATCTACGATGCATGCGTGCTTTATCCCGCGCCGTTGAGAGACTTCCTGATGTGGTT
GGGGTTATCAGGTCGGTTTCGGGCGCGATGGAGTCGCGAGATCCACGAGGAATGGAAGCGCAACCTGCTGCTTAATCGGC
AGGATCTGACGCGCGCGCAATTGGATCGAACCTCTGACTTGATGGATCGTGCCATTCCGGACGAGTTCATCGACAATCTG
TTCGATCTCGATGCGGCCGCGGTAGTGTCTGCCGCGCAGCGTCAGCGCGCGCAGCTTGTTCATCCCTCTATCGATGTCGA
CCGTTACCTGGACATCCTGCTCCGGCAGGGATTGGTGCAGACCGCGAAGGCGCTGGCGACGTATCGCGGCATCCTTTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17311.94 Da
• Isoelectric Point: 6.9925

>AT114741 WP_124687749.1 NZ_CP033966:759565-760029 [Pigmentiphaga sp. H8]
MVTAPSKMMLPVEREVQAAVQGQRALAAYLATRVETQRIQIFDDKNQAHQVELPTSALRLLVDILAELADGNAVRVVPVH
AELTTQEAADMLNVSRPHLVKLLEDGALPFHRTGKHRRVRFADLMRYKETRDLAAEQAMGELARQSQELKMGYE

Nucleotide

• Length: 465 bp

>AT114741 NZ_CP033966:759565-760029 [Pigmentiphaga sp. H8]
ATGGTCACCGCTCCGTCCAAGATGATGCTGCCCGTCGAGCGGGAAGTTCAGGCCGCCGTGCAAGGTCAGCGTGCACTGGC
TGCCTATCTGGCGACGCGTGTCGAAACGCAGCGGATTCAAATCTTCGACGATAAGAACCAGGCTCATCAGGTCGAGCTGC
CTACCTCAGCGCTGCGCCTGCTGGTGGACATACTGGCCGAACTGGCCGATGGCAATGCGGTGAGGGTCGTGCCTGTTCAC
GCCGAACTGACCACCCAGGAGGCCGCGGACATGCTCAATGTTTCGCGCCCGCATCTGGTCAAGCTATTGGAGGATGGCGC
GTTGCCTTTTCACCGGACGGGCAAGCATCGCCGCGTGCGGTTTGCCGATCTGATGCGGTACAAGGAGACGCGTGATCTCG
CCGCCGAGCAGGCCATGGGCGAACTTGCGCGGCAGTCGCAGGAGTTGAAGATGGGGTATGAATGA