Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 160171..161867 Replicon chromosome
Accession NZ_CP033966
Organism Pigmentiphaga sp. H8

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EGT29_RS00770 Protein ID WP_124687238.1
Coordinates 160974..161867 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EGT29_RS00765 Protein ID WP_124687237.1
Coordinates 160171..160971 (-) Length 267 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGT29_RS00745 155489..156463 + 975 WP_124687233.1 Twin-arginine translocation pathway signal -
EGT29_RS00750 156485..157723 - 1239 WP_124687234.1 polyamine aminopropyltransferase -
EGT29_RS00755 157969..158973 - 1005 WP_124687235.1 tripartite tricarboxylate transporter substrate binding protein -
EGT29_RS00760 159336..160142 - 807 WP_124687236.1 aspartate dehydrogenase -
EGT29_RS00765 160171..160971 - 801 WP_124687237.1 IclR family transcriptional regulator Antitoxin
EGT29_RS00770 160974..161867 - 894 WP_124687238.1 alpha/beta hydrolase Toxin
EGT29_RS00775 162165..162701 - 537 WP_124687239.1 cupin domain-containing protein -
EGT29_RS00780 163128..164564 + 1437 WP_124692159.1 DEAD/DEAH box helicase -
EGT29_RS00785 164783..166048 + 1266 WP_161567644.1 FAD-dependent monooxygenase -
EGT29_RS00790 166011..166538 - 528 WP_124687241.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-281)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31306.61 Da        Isoelectric Point: 6.4065

>T114739 WP_124687238.1 NZ_CP033966:c161867-160974 [Pigmentiphaga sp. H8]
MQTDTLAPEPSPETLELLNSRFAEKSVQTAGGVQCYREAGTPGADGMAIVLLHGIGSGAGSWLHAALKLAERARVIAWDA
PGYGNSARLAPASPGAGDYAQRLHQMLDALDIERCVLVGHSLGTLMATAYAHDLGKQRVARLVLLSPTRGYGNPALAERQ
EAVRAERLRTLEQVGIAGMARTRPAKMLSSEPSAEALAWVRWNMERLDTAGYRQAIEMLCNADMTGYAPAPVPVEVHSGD
QDTVTIPANCRAIAEMFGAPYGSIAVAGHACHIERPEAVAAILEGAHAAATAGATPR

Download         Length: 894 bp

>T114739 NZ_CP033966:c161867-160974 [Pigmentiphaga sp. H8]
ATGCAGACCGATACGTTGGCGCCGGAACCGTCGCCGGAAACGCTGGAGTTGCTCAATAGCCGTTTCGCCGAGAAGTCGGT
GCAGACGGCCGGGGGCGTGCAGTGTTATCGCGAGGCGGGCACGCCGGGCGCGGACGGCATGGCCATCGTGCTGTTGCATG
GCATCGGCTCGGGCGCGGGCTCGTGGCTGCATGCGGCGCTGAAGTTGGCCGAACGCGCGCGCGTGATCGCCTGGGACGCG
CCGGGCTACGGCAATTCGGCGCGGCTGGCGCCGGCCTCGCCGGGCGCCGGAGACTACGCACAGCGGCTGCACCAGATGCT
CGATGCGCTGGACATCGAACGCTGCGTGCTGGTGGGCCATTCGCTCGGCACGCTGATGGCCACGGCCTATGCGCATGACC
TGGGCAAACAGCGGGTCGCGCGGCTGGTGCTGCTGAGCCCCACCCGCGGCTACGGCAATCCGGCGCTGGCCGAGCGCCAG
GAAGCGGTGCGCGCCGAGCGGCTGCGCACGCTGGAACAGGTCGGCATCGCCGGCATGGCGCGCACGCGCCCCGCCAAGAT
GCTGTCGTCCGAACCCAGCGCCGAGGCCCTGGCCTGGGTGCGCTGGAACATGGAGCGCCTGGATACCGCCGGCTACCGCC
AGGCGATCGAGATGCTGTGCAACGCCGACATGACCGGCTACGCGCCGGCGCCCGTGCCGGTCGAGGTCCATTCCGGCGAC
CAGGACACCGTTACGATCCCGGCCAACTGCCGCGCCATCGCCGAGATGTTCGGCGCCCCCTACGGCTCCATCGCCGTGGC
CGGCCACGCCTGCCACATCGAGCGGCCCGAAGCGGTCGCGGCCATCCTGGAAGGCGCGCACGCCGCGGCCACCGCCGGCG
CCACGCCCCGCTGA

Antitoxin


Download         Length: 267 a.a.        Molecular weight: 29155.31 Da        Isoelectric Point: 6.6518

>AT114739 WP_124687237.1 NZ_CP033966:c160971-160171 [Pigmentiphaga sp. H8]
MNDAAISEDIPERYIVPGLERGLRLLSHFSRQNRTLSAPEFARKMGLPRSTVFRLLTTLEALGFIERTEGGRNYRLGMAV
LSLGFEYLASLELTELGSPLLQRLRDEIGYSCNLVVRDGRSIVYVAKVSAPTLFPSAVNLGTRLPAHATVLGRVMLTDLD
RQEMGELYPDEELEVYSPSTPPTLTALHGLLAQDRTNGYAMGAGFYEPSITSIATPVRDHTGRVIAALGAALPSSRVEQA
RVSELIGRVRGTADELSRLLNYSPSH

Download         Length: 801 bp

>AT114739 NZ_CP033966:c160971-160171 [Pigmentiphaga sp. H8]
ATGAACGACGCCGCCATCAGCGAAGACATTCCGGAGCGCTACATCGTCCCGGGCCTGGAGCGCGGCCTGCGGCTGCTCAG
CCACTTCAGCCGCCAGAACCGCACGCTGTCGGCGCCCGAGTTCGCGCGCAAGATGGGCCTGCCCCGCTCCACCGTGTTCC
GGCTGCTGACCACGCTGGAAGCGCTGGGTTTCATCGAGCGCACCGAGGGCGGCCGCAACTACCGGCTGGGCATGGCCGTG
CTGAGCCTGGGCTTCGAATACCTGGCCTCGCTGGAACTGACCGAACTCGGATCGCCGCTGCTGCAGCGCCTGCGGGACGA
GATCGGCTATTCCTGCAACCTGGTGGTGCGCGACGGCCGCTCCATCGTCTACGTCGCGAAGGTCTCGGCCCCCACGCTGT
TCCCCAGCGCGGTCAACCTGGGCACGCGCCTGCCCGCGCACGCCACCGTGCTCGGCCGCGTGATGCTGACCGACCTGGAC
CGCCAGGAAATGGGCGAACTCTATCCCGACGAGGAGCTGGAGGTCTATTCGCCCAGCACGCCGCCCACGCTGACGGCGCT
GCACGGCCTGCTGGCCCAGGACCGGACCAACGGCTATGCCATGGGCGCCGGCTTCTACGAACCCAGCATCACCAGCATCG
CCACGCCGGTGCGCGACCATACCGGCCGCGTGATCGCGGCGCTGGGCGCCGCACTGCCGTCCTCGCGCGTCGAGCAAGCG
CGCGTGTCCGAGCTGATCGGCCGGGTGCGCGGTACCGCCGACGAGCTGTCGCGCCTGCTCAACTATTCACCATCCCATTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References