Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4902658..4903174 Replicon chromosome
Accession NZ_CP033960
Organism Klebsiella pneumoniae strain L482

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag EHC63_RS24545 Protein ID WP_002886902.1
Coordinates 4902658..4902942 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EHC63_RS24550 Protein ID WP_002886901.1
Coordinates 4902932..4903174 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHC63_RS24525 4898142..4898450 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
EHC63_RS30630 4898535..4898708 + 174 WP_002886906.1 hypothetical protein -
EHC63_RS24530 4898711..4899454 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
EHC63_RS24535 4899811..4901949 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
EHC63_RS24540 4902190..4902654 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EHC63_RS24545 4902658..4902942 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHC63_RS24550 4902932..4903174 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EHC63_RS24555 4903252..4905162 - 1911 WP_004152270.1 BglG family transcription antiterminator -
EHC63_RS24560 4905185..4906339 - 1155 WP_002886900.1 lactonase family protein -
EHC63_RS24565 4906405..4907145 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T114722 WP_002886902.1 NZ_CP033960:c4902942-4902658 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T114722 NZ_CP033960:c4902942-4902658 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT114722 WP_002886901.1 NZ_CP033960:c4903174-4902932 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT114722 NZ_CP033960:c4903174-4902932 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References