Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 917791..918445 Replicon chromosome
Accession NZ_CP033960
Organism Klebsiella pneumoniae strain L482

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag EHC63_RS04785 Protein ID WP_004144731.1
Coordinates 918038..918445 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EHC63_RS04780 Protein ID WP_002916312.1
Coordinates 917791..918057 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHC63_RS04755 912947..914380 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
EHC63_RS04760 914499..915227 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EHC63_RS04765 915277..915588 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
EHC63_RS04770 915752..916411 + 660 WP_002916317.1 hemolysin III family protein -
EHC63_RS04775 916562..917545 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
EHC63_RS04780 917791..918057 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EHC63_RS04785 918038..918445 + 408 WP_004144731.1 protein YgfX Toxin
EHC63_RS04790 918452..918973 - 522 WP_002916308.1 flavodoxin FldB -
EHC63_RS04795 919074..919970 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EHC63_RS04800 919993..920706 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EHC63_RS04805 920712..922445 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T114710 WP_004144731.1 NZ_CP033960:918038-918445 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T114710 NZ_CP033960:918038-918445 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT114710 WP_002916312.1 NZ_CP033960:917791-918057 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT114710 NZ_CP033960:917791-918057 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References