Detailed information of TA system TA114673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4766695..4767211
• Replicon: chromosome
• Accession: NZ_CP033946
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EG819_RS23610
• Protein ID: WP_040216106.1
• Coordinates: 4766695..4766979 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EG819_RS23615
• Protein ID: WP_064162488.1
• Coordinates: 4766969..4767211 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG819_RS23590	4762112..4762420	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
EG819_RS28890	4762505..4762678	+	174	WP_032425422.1	hypothetical protein	-
EG819_RS23595	4762681..4763424	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
EG819_RS23600	4763781..4765919	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
EG819_RS23605	4766227..4766691	+	465	WP_064162487.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EG819_RS23610	4766695..4766979	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EG819_RS23615	4766969..4767211	-	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EG819_RS23620	4767289..4769199	-	1911	WP_023325426.1	BglG family transcription antiterminator	-
EG819_RS23625	4769222..4770376	-	1155	WP_064162489.1	lactonase family protein	-
EG819_RS23630	4770443..4771183	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T114673 WP_040216106.1 NZ_CP033946:c4766979-4766695 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T114673 NZ_CP033946:c4766979-4766695 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT114673 WP_064162488.1 NZ_CP033946:c4767211-4766969 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT114673 NZ_CP033946:c4767211-4766969 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA