Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 43702..44345 | Replicon | plasmid pPSEM90-6 |
| Accession | NZ_CP033943 | ||
| Organism | Piscirickettsia salmonis strain EM-90 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | E9LHC6 |
| Locus tag | EG881_RS19070 | Protein ID | WP_016210974.1 |
| Coordinates | 43702..44109 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | E9LHC5 |
| Locus tag | EG881_RS19075 | Protein ID | WP_016210972.1 |
| Coordinates | 44118..44345 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EG881_RS19030 | 39462..39779 | - | 318 | WP_164997282.1 | hypothetical protein | - |
| EG881_RS19035 | 39834..40043 | - | 210 | WP_016212231.1 | hypothetical protein | - |
| EG881_RS19040 | 40047..40526 | - | 480 | WP_016212234.1 | P27 family phage terminase small subunit | - |
| EG881_RS19045 | 40614..40996 | - | 383 | Protein_54 | HNH endonuclease | - |
| EG881_RS19050 | 41297..41662 | - | 366 | WP_016212235.1 | hypothetical protein | - |
| EG881_RS20720 | 41709..41888 | + | 180 | WP_155046773.1 | phosphatase | - |
| EG881_RS19055 | 42033..42215 | + | 183 | WP_129556724.1 | hypothetical protein | - |
| EG881_RS19060 | 42433..42726 | - | 294 | WP_016210977.1 | zinc ribbon domain-containing protein | - |
| EG881_RS19065 | 42905..43585 | - | 681 | WP_129556725.1 | DNA/RNA non-specific endonuclease | - |
| EG881_RS19070 | 43702..44109 | - | 408 | WP_016210974.1 | DUF4411 family protein | Toxin |
| EG881_RS19075 | 44118..44345 | - | 228 | WP_016210972.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| EG881_RS19080 | 44493..44885 | - | 393 | WP_129556726.1 | hypothetical protein | - |
| EG881_RS19085 | 45000..45473 | - | 474 | WP_016210960.1 | single-stranded DNA-binding protein | - |
| EG881_RS19090 | 45475..45759 | - | 285 | WP_036794070.1 | hypothetical protein | - |
| EG881_RS19095 | 45756..46043 | - | 288 | WP_036794065.1 | hypothetical protein | - |
| EG881_RS19100 | 46139..46378 | - | 240 | WP_016210963.1 | hypothetical protein | - |
| EG881_RS19105 | 46375..46722 | - | 348 | WP_016210966.1 | hypothetical protein | - |
| EG881_RS19110 | 46715..47077 | - | 363 | WP_016210959.1 | hypothetical protein | - |
| EG881_RS19115 | 47046..47606 | - | 561 | WP_016210973.1 | hypothetical protein | - |
| EG881_RS19120 | 47629..48444 | - | 816 | WP_016210962.1 | hypothetical protein | - |
| EG881_RS19125 | 48491..48790 | - | 300 | WP_016210976.1 | hypothetical protein | - |
| EG881_RS19130 | 48944..49249 | - | 306 | WP_016210958.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..91336 | 91336 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15625.00 Da Isoelectric Point: 7.4170
>T114657 WP_016210974.1 NZ_CP033943:c44109-43702 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLEVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVEHLEFEDWAS
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLEVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVEHLEFEDWAS
Download Length: 408 bp
>T114657 NZ_CP033943:c44109-43702 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAGCCTCGTTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCCATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGGAGTCAAC
ACCAGCGAAAAAACCAGGAAGCGATTAATACCTTGGTAAATAAGCTAGAAGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCGCATGC
GCTCTCAGAAAAAGCCGTTTTAGTGACACATAATACAAAAGAGTTTCAGCGTGTCGAGCATTTAGAGTTTGAAGACTGGG
CAAGTTAA
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAGCCTCGTTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCCATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGGAGTCAAC
ACCAGCGAAAAAACCAGGAAGCGATTAATACCTTGGTAAATAAGCTAGAAGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCGCATGC
GCTCTCAGAAAAAGCCGTTTTAGTGACACATAATACAAAAGAGTTTCAGCGTGTCGAGCATTTAGAGTTTGAAGACTGGG
CAAGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8929.02 Da Isoelectric Point: 4.5679
>AT114657 WP_016210972.1 NZ_CP033943:c44345-44118 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDHQDIQAQERDWF
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDHQDIQAQERDWF
Download Length: 228 bp
>AT114657 NZ_CP033943:c44345-44118 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCCCAAGCCGTTCGGTTACCGAAAGAAATGCGGCTGGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAAGATCATCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCCCAAGCCGTTCGGTTACCGAAAGAAATGCGGCTGGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAAGATCATCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|