Detailed information of TA system TA114656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 26287..26818
• Replicon: plasmid pPSEM90-6
• Accession: NZ_CP033943
• Organism: Piscirickettsia salmonis strain EM-90

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EG881_RS18940
• Protein ID: WP_016210662.1
• Coordinates: 26531..26818 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EG881_RS18935
• Protein ID: WP_016210670.1
• Coordinates: 26287..26541 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG881_RS18925	21767..22906	-	1140	WP_032126910.1	hypothetical protein	-
EG881_RS18930	22906..26193	-	3288	WP_016210653.1	host specificity protein J	-
EG881_RS18935	26287..26541	+	255	WP_016210670.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EG881_RS18940	26531..26818	+	288	WP_016210662.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EG881_RS18945	26825..27382	-	558	WP_016210665.1	tail assembly protein	-
EG881_RS18950	27372..28118	-	747	WP_032126911.1	C40 family peptidase	-
EG881_RS18955	28087..28758	-	672	WP_016210666.1	phage minor tail protein L	-
EG881_RS18960	28755..29096	-	342	WP_016210657.1	phage tail protein	-
EG881_RS18965	29089..31167	-	2079	WP_032126912.1	hypothetical protein	-
EG881_RS18970	31171..31437	-	267	WP_016211142.1	DUF4035 domain-containing protein	-
EG881_RS18975	31494..31817	-	324	WP_032126913.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91336	91336

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11064.15 Da
• Isoelectric Point: 10.7358

>T114656 WP_016210662.1 NZ_CP033943:26531-26818 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKEDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T114656 NZ_CP033943:26531-26818 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAGAGGATAAAGTGGTTGTTCAAGTCTTGGCGATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9450.69 Da
• Isoelectric Point: 4.0808

>AT114656 WP_016210670.1 NZ_CP033943:26287-26541 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNAPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLNSPDCDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT114656 NZ_CP033943:26287-26541 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACCATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATTAATGAAGCCAA
CGGCGAGCCGGTGGTTATTTTGAATCATAATGCTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTGAATTCTCCTGATTGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA