Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 127293..127863 Replicon plasmid pPSEM90-5
Accession NZ_CP033942
Organism Piscirickettsia salmonis strain EM-90

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EG881_RS18460 Protein ID WP_129556708.1
Coordinates 127293..127628 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EG881_RS18465 Protein ID WP_016212365.1
Coordinates 127621..127863 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG881_RS18425 122969..123346 + 378 Protein_169 DDE-type integrase/transposase/recombinase -
EG881_RS18430 123447..124226 + 780 WP_081377351.1 transposase -
EG881_RS18440 124415..124747 + 333 WP_032126739.1 transposase -
EG881_RS18445 124912..125289 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
EG881_RS18450 125596..125979 - 384 WP_016212152.1 hypothetical protein -
EG881_RS18455 126449..127177 - 729 WP_054300202.1 IS6 family transposase -
EG881_RS18460 127293..127628 - 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EG881_RS18465 127621..127863 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
EG881_RS18470 128072..129046 + 975 WP_054300271.1 IS30 family transposase -
EG881_RS18475 129174..129614 + 441 Protein_178 tyrosine-type recombinase/integrase -
EG881_RS18480 129682..130410 + 729 WP_075275142.1 IS6 family transposase -
EG881_RS18485 130693..132378 + 1686 WP_075275141.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..167750 167750
- inside IScluster/Tn - - 100935..134118 33183


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T114655 WP_129556708.1 NZ_CP033942:c127628-127293 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T114655 NZ_CP033942:c127628-127293 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT114655 WP_016212365.1 NZ_CP033942:c127863-127621 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT114655 NZ_CP033942:c127863-127621 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References