Detailed information of TA system TA114653

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3267430..3268028
• Replicon: chromosome
• Accession: NZ_CP033936
• Organism: Kerstersia gyiorum strain SWMUKG01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHF36_RS14310
• Protein ID: WP_134838817.1
• Coordinates: 3267430..3267735 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A171KW16
• Locus tag: EHF36_RS14315
• Protein ID: WP_068366953.1
• Coordinates: 3267732..3268028 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHF36_RS14280	3263143..3264126	+	984	WP_068367753.1	ABC transporter permease	-
EHF36_RS14285	3264244..3264621	+	378	WP_205704121.1	VOC family protein	-
EHF36_RS14290	3264747..3266042	-	1296	WP_068366945.1	MHS family MFS transporter	-
EHF36_RS14300	3266426..3267016	+	591	WP_068366948.1	XRE family transcriptional regulator	-
EHF36_RS14305	3267057..3267266	+	210	WP_134838816.1	DNA-binding protein	-
EHF36_RS14310	3267430..3267735	+	306	WP_134838817.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHF36_RS14315	3267732..3268028	+	297	WP_068366953.1	putative addiction module antidote protein	Antitoxin
EHF36_RS14320	3268736..3269254	-	519	WP_035271806.1	GNAT family N-acetyltransferase	-
EHF36_RS14325	3269388..3270248	-	861	WP_068366966.1	class I SAM-dependent methyltransferase	-
EHF36_RS14330	3270311..3271309	-	999	WP_071535909.1	MerR family transcriptional regulator	-
EHF36_RS14335	3271608..3271868	-	261	WP_134838818.1	DUF4279 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3260415..3274879	14464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (6-92)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11390.13 Da
• Isoelectric Point: 10.0247

>T114653 WP_134838817.1 NZ_CP033936:3267430-3267735 [Kerstersia gyiorum]
MNTINLAEEFGRWLSSLKDVMGKAKILARIRNASLGNFGDIKPIGDGVSEMRIDFGPGYRVYYAREGRVVYLLLHGGDKS
AQQKDIATAIRMWKKIQEEQS

Nucleotide

• Length: 306 bp

>T114653 NZ_CP033936:3267430-3267735 [Kerstersia gyiorum]
ATGAACACGATCAACCTCGCCGAAGAGTTTGGCCGGTGGCTTTCAAGCCTCAAAGATGTGATGGGCAAAGCCAAGATCCT
CGCTCGCATCAGGAATGCCAGCTTGGGAAACTTTGGTGACATCAAACCTATTGGCGACGGCGTCTCAGAAATGCGGATTG
ATTTCGGCCCAGGCTACCGTGTCTACTACGCCCGAGAAGGGCGCGTGGTTTATCTCCTGCTTCATGGTGGCGACAAGTCC
GCCCAACAGAAAGACATCGCGACTGCCATCAGGATGTGGAAAAAAATTCAAGAGGAACAATCATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10401.99 Da
• Isoelectric Point: 5.1052

>AT114653 WP_068366953.1 NZ_CP033936:3267732-3268028 [Kerstersia gyiorum]
MTAIKTVPFDAAEYLDNEEAIAAYLSAALEENEPALFLAALADVAKARGMTKMAQDAGLGRESLYKALAPGAKPRYDTVL
KLARAAGVRLTVEPIPSH

Nucleotide

• Length: 297 bp

>AT114653 NZ_CP033936:3267732-3268028 [Kerstersia gyiorum]
ATGACCGCCATCAAAACCGTCCCGTTCGATGCTGCGGAATACCTCGACAACGAAGAAGCGATTGCAGCCTATCTGTCTGC
CGCCCTGGAAGAGAATGAACCGGCGCTCTTTCTGGCTGCACTCGCAGATGTGGCCAAGGCACGCGGCATGACAAAAATGG
CTCAAGATGCAGGACTAGGCCGTGAAAGCCTGTACAAAGCACTGGCGCCTGGTGCAAAGCCACGATACGACACAGTGCTC
AAGCTGGCACGTGCCGCTGGCGTGAGACTAACCGTGGAGCCGATTCCATCCCATTGA

Structures

Antitoxin

• AlphaFold DB: A0A171KW16