Detailed information of TA system TA114652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-tacA/DUF1778(antitoxin)
• Location: 1087883..1088673
• Replicon: chromosome
• Accession: NZ_CP033936
• Organism: Kerstersia gyiorum strain SWMUKG01

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: EHF36_RS04720
• Protein ID: WP_134838182.1
• Coordinates: 1087883..1088395 (-)
• Length: 171 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: EHF36_RS04725
• Protein ID: WP_134838183.1
• Coordinates: 1088395..1088673 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHF36_RS04690	1083125..1084336	-	1212	WP_134838176.1	MFS transporter	-
EHF36_RS17310	1084333..1084509	-	177	WP_167731846.1	hypothetical protein	-
EHF36_RS04695	1085186..1085542	-	357	WP_134838177.1	DDE-type integrase/transposase/recombinase	-
EHF36_RS04700	1085425..1085661	-	237	WP_134838178.1	DDE-type integrase/transposase/recombinase	-
EHF36_RS04705	1085795..1086112	-	318	WP_134838179.1	hypothetical protein	-
EHF36_RS04710	1086418..1086756	+	339	WP_134838180.1	hypothetical protein	-
EHF36_RS04715	1086725..1087300	+	576	WP_205704139.1	hypothetical protein	-
EHF36_RS04720	1087883..1088395	-	513	WP_134838182.1	GNAT family N-acetyltransferase	Toxin
EHF36_RS04725	1088395..1088673	-	279	WP_134838183.1	DUF1778 domain-containing protein	Antitoxin
EHF36_RS04730	1088898..1089521	+	624	WP_134838184.1	hypothetical protein	-
EHF36_RS04740	1089901..1090959	+	1059	WP_134838983.1	UDP-N-acetylmuramate dehydrogenase	-
EHF36_RS04745	1091232..1092023	-	792	WP_134838185.1	4-hydroxy-tetrahydrodipicolinate reductase	-
EHF36_RS04750	1092079..1092660	-	582	WP_134838186.1	outer membrane protein assembly factor BamE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1085186..1085320	134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (53-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (10-86)

Sequences

Toxin

Protein

• Length: 171 a.a.
• Molecular weight: 18757.61 Da
• Isoelectric Point: 8.0630

>T114652 WP_134838182.1 NZ_CP033936:c1088395-1087883 [Kerstersia gyiorum]
MSLTAPQALDASHILDEFDCSKDSMNEWLIRHARQAQASGSAKTYVVAPNQDPRVVGYYSLTVGQIDTLEAPERVRRGMG
SYPIPVVILARLAVARQLHGQGLGIGLLQDAIRRTVAISEQAGVRALLTHPIDAEAEQFYLRFGFEASPVREQQLLLLLK
DARKLLLTKP

Nucleotide

• Length: 513 bp

>T114652 NZ_CP033936:c1088395-1087883 [Kerstersia gyiorum]
ATGTCGCTGACAGCGCCCCAGGCGCTGGATGCCAGCCATATCCTTGACGAGTTTGATTGCAGCAAGGACAGCATGAACGA
ATGGCTAATTCGTCATGCTCGCCAAGCACAAGCCAGCGGCTCCGCCAAGACGTATGTGGTCGCGCCCAACCAGGATCCGC
GTGTCGTTGGCTACTACAGCCTCACCGTGGGTCAAATCGACACGCTGGAAGCGCCTGAACGGGTGCGCCGTGGCATGGGC
AGCTACCCCATCCCCGTGGTCATTCTGGCGCGGCTGGCAGTCGCCCGGCAATTGCATGGACAGGGTCTGGGCATTGGTCT
GCTGCAAGACGCGATCCGTCGCACCGTGGCGATTTCCGAACAGGCTGGCGTGCGGGCCTTGTTAACGCATCCTATCGACG
CAGAGGCTGAACAGTTCTACCTACGCTTCGGCTTCGAAGCCTCTCCTGTGCGGGAACAACAACTGCTGCTTCTGCTCAAG
GATGCACGCAAATTGCTGCTGACCAAGCCTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10273.64 Da
• Isoelectric Point: 7.0105

>AT114652 WP_134838183.1 NZ_CP033936:c1088673-1088395 [Kerstersia gyiorum]
MTATTMRSGRIGFRVLPQQEAVLRRAAEVSHKSLTDFILDSAYQAAEQTLLDQRLFLVAGSQSQALLDLLDRPAQANEGL
QNLFSRTAPWDR

Nucleotide

• Length: 279 bp

>AT114652 NZ_CP033936:c1088673-1088395 [Kerstersia gyiorum]
ATGACCGCAACCACAATGCGTTCTGGACGCATCGGTTTTCGAGTGCTCCCGCAGCAAGAAGCCGTGCTGCGGCGAGCCGC
CGAAGTCAGCCACAAGTCCTTGACCGACTTCATCCTTGACAGTGCCTATCAGGCCGCCGAGCAAACCCTGCTGGATCAGC
GCCTGTTCTTGGTTGCGGGTAGCCAATCGCAGGCTCTGCTGGATTTGCTCGACCGGCCAGCACAGGCCAATGAAGGTCTT
CAAAACCTGTTCTCTCGTACTGCGCCGTGGGATCGCTGA