Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 304461..306241 Replicon chromosome
Accession NZ_CP033936
Organism Kerstersia gyiorum strain SWMUKG01

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EHF36_RS01285 Protein ID WP_127772990.1
Coordinates 304461..305393 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A171KRY5
Locus tag EHF36_RS01290 Protein ID WP_068371498.1
Coordinates 305390..306241 (+) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF36_RS01260 300260..301042 + 783 WP_083969606.1 ABC transporter ATP-binding protein -
EHF36_RS01265 301122..302123 + 1002 WP_130487642.1 ABC transporter substrate-binding protein -
EHF36_RS01270 302163..302939 + 777 WP_068371507.1 ABC transporter permease -
EHF36_RS01275 303024..303791 + 768 WP_205704156.1 SDR family oxidoreductase -
EHF36_RS01280 303871..304419 + 549 WP_134837956.1 cupin domain-containing protein -
EHF36_RS01285 304461..305393 + 933 WP_127772990.1 alpha/beta hydrolase Toxin
EHF36_RS01290 305390..306241 + 852 WP_068371498.1 IclR family transcriptional regulator Antitoxin
EHF36_RS01295 306247..307122 + 876 WP_134838959.1 SDR family oxidoreductase -
EHF36_RS01300 307115..308827 + 1713 WP_068371496.1 thiamine pyrophosphate-binding protein -
EHF36_RS01305 308844..309635 + 792 WP_068371635.1 aspartate dehydrogenase -
EHF36_RS01310 309673..311154 + 1482 WP_068371494.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-291)

Antitoxin

Transcription regulator IclR, N-terminal

(21-71)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 32724.69 Da        Isoelectric Point: 6.2278

>T114651 WP_127772990.1 NZ_CP033936:304461-305393 [Kerstersia gyiorum]
MTEILTAPPAITAEQLADLEATFGLFNIRLADGTVVSVRDTVAGDVRKPVLVCLHGIGSGAASWLELARIFNLRHRVLAW
DAPGYGESTPLPGAAPSALDYAEALHRVLVSLSIDDFVLVGHSLGALVAAAYTAHRWPGCRPRALVLISPAQGYGALARE
ARGREVRQQRLAEVTREGGMPAMAARRYLRLLGPGADRRAQAWVYWNMARLQGPGYAQAVELLCGGDLLADCRRIAVAQG
PVPVQVWCGTEDIVTPPAACAEVAAALDVSLQPIEGAGHACYVEQPAVLAALLTQVLLGLPAQPDQGVNG

Download         Length: 933 bp

>T114651 NZ_CP033936:304461-305393 [Kerstersia gyiorum]
ATGACTGAGATCCTTACTGCCCCTCCGGCCATTACCGCCGAGCAACTCGCGGACCTGGAAGCCACGTTCGGCCTGTTCAA
CATCCGCCTGGCGGATGGCACGGTCGTTTCCGTGCGGGACACCGTGGCGGGCGACGTCCGCAAGCCTGTCCTGGTCTGTT
TGCACGGCATTGGCTCGGGGGCGGCGTCGTGGCTGGAACTGGCGCGCATCTTCAACCTGCGGCACCGCGTGCTGGCCTGG
GATGCGCCTGGCTATGGCGAATCCACGCCATTGCCCGGCGCCGCGCCCTCGGCACTGGATTATGCCGAGGCGCTGCACCG
CGTGCTGGTGTCGCTTTCCATTGACGATTTCGTGCTGGTGGGGCACTCGCTGGGCGCTCTGGTGGCTGCTGCCTACACCG
CACACCGCTGGCCAGGCTGTCGACCGCGTGCGTTGGTGCTGATCAGCCCGGCGCAGGGCTATGGCGCCCTGGCCCGCGAA
GCACGGGGCCGGGAAGTACGGCAGCAGCGTCTGGCCGAAGTGACCCGGGAAGGCGGCATGCCGGCGATGGCGGCGCGCCG
CTACCTGCGCCTGTTGGGGCCTGGCGCAGACCGCCGTGCGCAGGCATGGGTGTACTGGAATATGGCACGCCTGCAGGGGC
CGGGCTATGCCCAGGCGGTGGAACTGCTGTGTGGCGGGGATCTGCTGGCCGACTGCAGGCGTATTGCCGTGGCCCAGGGG
CCGGTGCCCGTGCAGGTGTGGTGCGGCACCGAGGATATTGTCACCCCGCCCGCCGCCTGTGCGGAGGTGGCGGCCGCACT
GGACGTGTCCTTGCAGCCCATCGAGGGCGCCGGGCACGCCTGTTATGTGGAGCAGCCGGCAGTGCTGGCTGCCCTGTTGA
CGCAGGTATTGCTGGGCCTGCCTGCCCAACCCGATCAAGGAGTCAACGGATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 31314.91 Da        Isoelectric Point: 6.8433

>AT114651 WP_068371498.1 NZ_CP033936:305390-306241 [Kerstersia gyiorum]
MNEQTAINNQDDEALRYIVPALERGLLILSQFSREKRQIGAPELTQRLQLPRSTVFRLLNTLEYMGYLERSENGREYKLG
LGVLRLGFEYLASLDLTELGTPLINRLCHEVGHAANLVVRDGQNIVYVAKTTTSNTPFIGSVSVGTRLPAHATALGHVLL
GGLTLAQLKELYPEHSLEVFSPQTPKDVNELYESAVRIRERGYVAAEGFYELHISTVAAPVYNHQGQIVAALGVTLGMRQ
IDQAQKLMLIDSVCQVANELSGLLDYAPAQQRRKAPYIMKGAA

Download         Length: 852 bp

>AT114651 NZ_CP033936:305390-306241 [Kerstersia gyiorum]
ATGAACGAGCAAACCGCTATCAACAACCAGGACGATGAGGCGCTCCGATACATCGTGCCAGCGCTGGAGCGCGGCCTGCT
GATACTGAGCCAGTTCAGCCGCGAGAAGCGCCAGATTGGCGCGCCGGAATTGACGCAGCGCCTGCAGTTGCCGCGTTCCA
CTGTGTTCCGTCTGCTCAACACGCTGGAGTACATGGGCTATCTGGAGCGTTCGGAGAATGGCCGGGAATACAAGCTGGGC
CTGGGCGTGCTGCGCCTGGGCTTCGAATACCTGGCCTCCCTGGACCTGACCGAACTGGGCACGCCGCTGATCAACCGCCT
GTGCCATGAGGTCGGCCATGCCGCCAATCTGGTGGTACGCGACGGGCAGAACATCGTGTATGTCGCCAAGACGACGACCT
CGAACACGCCGTTCATCGGTTCCGTCTCGGTGGGCACCCGTCTGCCTGCGCATGCGACGGCTCTTGGGCACGTGCTGCTG
GGTGGCCTGACGCTGGCGCAGCTCAAGGAACTGTATCCGGAACACAGCCTGGAAGTGTTTTCGCCTCAGACTCCCAAGGA
CGTCAATGAGCTGTACGAATCCGCCGTGCGGATACGCGAACGCGGGTATGTGGCGGCCGAAGGGTTCTACGAATTGCATA
TCTCCACCGTGGCGGCACCGGTCTACAACCACCAGGGACAGATCGTTGCGGCGCTGGGCGTCACGCTGGGCATGCGGCAG
ATAGACCAGGCGCAGAAGCTGATGCTCATCGACAGCGTGTGCCAGGTGGCCAATGAGTTGTCGGGCCTGCTCGACTACGC
ACCGGCACAGCAGCGCCGCAAGGCGCCGTACATCATGAAAGGAGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A171KRY5

References