Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1658332..1658944 Replicon chromosome
Accession NZ_CP033907
Organism Streptococcus pyogenes strain Duke-Large

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag EHF40_RS08615 Protein ID WP_002988077.1
Coordinates 1658609..1658944 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag EHF40_RS08610 Protein ID WP_002988079.1
Coordinates 1658332..1658619 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHF40_RS08585 1653521..1654504 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
EHF40_RS08590 1654508..1655437 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
EHF40_RS08595 1655485..1656000 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
EHF40_RS08600 1656035..1656463 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
EHF40_RS08605 1656909..1657682 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
EHF40_RS08610 1658332..1658619 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
EHF40_RS08615 1658609..1658944 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHF40_RS08620 1659083..1659259 + 177 Protein_1589 tyrosine-type recombinase/integrase -
EHF40_RS08630 1659390..1659782 - 393 WP_002982716.1 30S ribosomal protein S9 -
EHF40_RS08635 1659803..1660249 - 447 WP_002982710.1 50S ribosomal protein L13 -
EHF40_RS08640 1660467..1660673 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
EHF40_RS08645 1660670..1661368 - 699 WP_021299047.1 hypothetical protein -
EHF40_RS08650 1661504..1662364 - 861 WP_011529009.1 DegV family protein -
EHF40_RS08655 1662461..1662979 - 519 WP_011055010.1 NYN domain-containing protein -
EHF40_RS08660 1662983..1663729 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T114633 WP_002988077.1 NZ_CP033907:1658609-1658944 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T114633 NZ_CP033907:1658609-1658944 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT114633 WP_002988079.1 NZ_CP033907:1658332-1658619 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT114633 NZ_CP033907:1658332-1658619 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References