Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1198653..1199251 Replicon chromosome
Accession NZ_CP033905
Organism Trueperella pyogenes strain TP4

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EBQ10_RS05650 Protein ID WP_108726552.1
Coordinates 1198653..1198967 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EBQ10_RS05655 Protein ID WP_108726551.1
Coordinates 1198958..1199251 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBQ10_RS05620 1193686..1194603 - 918 WP_108726555.1 ABC transporter substrate-binding protein -
EBQ10_RS05625 1194712..1194954 + 243 WP_024963636.1 hypothetical protein -
EBQ10_RS05630 1194951..1195904 + 954 WP_108726554.1 SRPBCC family protein -
EBQ10_RS05635 1196048..1196659 + 612 WP_039663456.1 alpha/beta hydrolase -
EBQ10_RS05640 1196791..1197147 - 357 WP_039661774.1 hypothetical protein -
EBQ10_RS05645 1197475..1198323 - 849 WP_164717795.1 siderophore-interacting protein -
EBQ10_RS05650 1198653..1198967 + 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EBQ10_RS05655 1198958..1199251 + 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
EBQ10_RS05660 1199358..1199774 + 417 WP_108726550.1 SRPBCC family protein -
EBQ10_RS05670 1200174..1200800 - 627 WP_108726549.1 alpha/beta fold hydrolase -
EBQ10_RS05675 1200797..1201816 - 1020 WP_039661764.1 hypothetical protein -
EBQ10_RS05680 1201876..1203090 - 1215 WP_108726548.1 molybdopterin molybdotransferase MoeA -
EBQ10_RS05685 1203174..1203821 + 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1195952..1210401 14449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T114632 WP_108726552.1 NZ_CP033905:1198653-1198967 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

>T114632 NZ_CP033905:1198653-1198967 [Trueperella pyogenes]
GTGAAGATTCGGCAAACCGACGTGTATGCTCACTGGTTTCGCGAGCTAAAAGATGTCCAGAGCAAGGCCCGAATCAATAT
TGCACTTCAGCGTTGCAAAATAGCTGGCGAAGTAGTGGGTGACGTCAAGCCGGTTGGTGATGGCGTTTTTGAGATGCGAA
TTCACGTTGGCCCCGGCTATCGGATTTACTACATGTCAAGAGGGAACCAACTTATGCTACTAGTCATTGGTGGTGATAAG
TCCACCCAGCAGCGTGACATAACCAAAGCTAAACAGCTTGCAACAGAAATTATTAGGGAGGGATCATGGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT114632 WP_108726551.1 NZ_CP033905:1198958-1199251 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT114632 NZ_CP033905:1198958-1199251 [Trueperella pyogenes]
ATGGGAGTAAAAATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAGGAAGATATTGCTGCCTACCTGAACGCGGC
ACTCGAAGAGGGCGACCCGGCTCTCCTGCAGGTCGCACTTGGTGATGTCGCCAAAGCGCGTGGTGTGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGCAATCCGTCCTGGCGGACCATCACAAAG
GTTCTCACTGCACTCGGGCTGAAGATCGAAGTCAAAGCCATTGCGTTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References