Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2230992..2231590 Replicon chromosome
Accession NZ_CP033904
Organism Trueperella pyogenes strain TP3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EBQ11_RS09995 Protein ID WP_108726552.1
Coordinates 2231276..2231590 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EBQ11_RS09990 Protein ID WP_108726551.1
Coordinates 2230992..2231285 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EBQ11_RS09960 2226422..2227069 - 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -
EBQ11_RS09965 2227153..2228367 + 1215 WP_108726548.1 molybdopterin molybdotransferase MoeA -
EBQ11_RS09970 2228427..2229446 + 1020 WP_039661764.1 hypothetical protein -
EBQ11_RS09975 2229443..2230069 + 627 WP_108726549.1 alpha/beta fold hydrolase -
EBQ11_RS09985 2230469..2230885 - 417 WP_108726550.1 SRPBCC family protein -
EBQ11_RS09990 2230992..2231285 - 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
EBQ11_RS09995 2231276..2231590 - 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EBQ11_RS10000 2231920..2232768 + 849 WP_159081093.1 siderophore-interacting protein -
EBQ11_RS10005 2233096..2233452 + 357 WP_039661774.1 hypothetical protein -
EBQ11_RS10010 2233584..2234195 - 612 WP_039663456.1 alpha/beta hydrolase -
EBQ11_RS10015 2234339..2235292 - 954 WP_108726554.1 SRPBCC family protein -
EBQ11_RS10020 2235289..2235531 - 243 WP_024963636.1 hypothetical protein -
EBQ11_RS10025 2235640..2236557 + 918 WP_108726555.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2230469..2243386 12917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T114631 WP_108726552.1 NZ_CP033904:c2231590-2231276 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

>T114631 NZ_CP033904:c2231590-2231276 [Trueperella pyogenes]
GTGAAGATTCGGCAAACCGACGTGTATGCTCACTGGTTTCGCGAGCTAAAAGATGTCCAGAGCAAGGCCCGAATCAATAT
TGCACTTCAGCGTTGCAAAATAGCTGGCGAAGTAGTGGGTGACGTCAAGCCGGTTGGTGATGGCGTTTTTGAGATGCGAA
TTCACGTTGGCCCCGGCTATCGGATTTACTACATGTCAAGAGGGAACCAACTTATGCTACTAGTCATTGGTGGTGATAAG
TCCACCCAGCAGCGTGACATAACCAAAGCTAAACAGCTTGCAACAGAAATTATTAGGGAGGGATCATGGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT114631 WP_108726551.1 NZ_CP033904:c2231285-2230992 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT114631 NZ_CP033904:c2231285-2230992 [Trueperella pyogenes]
ATGGGAGTAAAAATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAGGAAGATATTGCTGCCTACCTGAACGCGGC
ACTCGAAGAGGGCGACCCGGCTCTCCTGCAGGTCGCACTTGGTGATGTCGCCAAAGCGCGTGGTGTGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGCAATCCGTCCTGGCGGACCATCACAAAG
GTTCTCACTGCACTCGGGCTGAAGATCGAAGTCAAAGCCATTGCGTTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References