Detailed information of TA system TA114625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4930240..4930835
• Replicon: chromosome
• Accession: NZ_CP033893
• Organism: Serratia liquefaciens strain FG3

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: EGO53_RS23930
• Protein ID: WP_142816192.1
• Coordinates: 4930240..4930617 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: EGO53_RS23935
• Protein ID: WP_142816193.1
• Coordinates: 4930614..4930835 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO53_RS23900	4925369..4925986	-	618	WP_020837649.1	trimeric intracellular cation channel family protein	-
EGO53_RS23905	4926281..4926715	+	435	WP_142816189.1	DUF3574 domain-containing protein	-
EGO53_RS23910	4926747..4927931	-	1185	WP_020837645.1	hypothetical protein	-
EGO53_RS23915	4928268..4929008	+	741	WP_122080475.1	SDR family oxidoreductase	-
EGO53_RS23920	4929297..4929755	-	459	WP_142816190.1	hypothetical protein	-
EGO53_RS23925	4929795..4930175	-	381	WP_142816191.1	hypothetical protein	-
EGO53_RS23930	4930240..4930617	-	378	WP_142816192.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
EGO53_RS23935	4930614..4930835	-	222	WP_142816193.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EGO53_RS23940	4931193..4931381	-	189	WP_142816194.1	hypothetical protein	-
EGO53_RS23945	4931477..4931866	-	390	WP_142816195.1	hypothetical protein	-
EGO53_RS29275	4932427..4933074	-	648	WP_185959360.1	hypothetical protein	-
EGO53_RS23955	4933092..4933316	-	225	WP_142816196.1	PerC family transcriptional regulator	-
EGO53_RS23960	4933313..4933795	-	483	WP_142816469.1	ProQ/FinO family protein	-
EGO53_RS23965	4933852..4934304	-	453	WP_142816197.1	single-stranded DNA-binding protein	-
EGO53_RS23970	4934301..4934621	-	321	WP_142816198.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4929297..4947403	18106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14028.94 Da
• Isoelectric Point: 5.1828

>T114625 WP_142816192.1 NZ_CP033893:c4930617-4930240 [Serratia liquefaciens]
MRWISASEVLIFHDRILQRFPGVQGMPDAGRAEAIIHRVQNLAHYEGVTDLFELAAAYWVAIARGHIFNDGNKRTAFFTT
MAFLGRNGVEIRDEGNELEELTVCAATGEMPPSQLAQRLRELVES

Nucleotide

• Length: 378 bp

>T114625 NZ_CP033893:c4930617-4930240 [Serratia liquefaciens]
ATGAGATGGATTAGCGCCAGTGAGGTACTGATATTTCACGACAGAATTTTGCAGCGTTTCCCCGGTGTGCAAGGCATGCC
AGATGCGGGAAGGGCCGAAGCCATCATTCATCGCGTGCAGAACCTGGCGCACTATGAAGGCGTAACGGATTTGTTCGAGC
TGGCCGCCGCGTATTGGGTAGCCATTGCCCGCGGGCATATCTTTAACGATGGCAACAAGCGCACAGCATTTTTTACCACG
ATGGCCTTTTTGGGGCGCAACGGCGTAGAGATCCGCGATGAGGGCAACGAACTGGAGGAACTGACCGTGTGCGCGGCAAC
CGGTGAAATGCCCCCGAGCCAGTTGGCGCAGCGGCTGCGAGAATTGGTTGAAAGCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8032.06 Da
• Isoelectric Point: 5.6400

>AT114625 WP_142816193.1 NZ_CP033893:c4930835-4930614 [Serratia liquefaciens]
MIIYTSTQARANIAAVLDAATNGEPVEIIRRDGSAAVVISKADFEAYQKAKLDAEFDHIMQRHGRTVEALTDR

Nucleotide

• Length: 222 bp

>AT114625 NZ_CP033893:c4930835-4930614 [Serratia liquefaciens]
ATGATTATCTATACATCAACCCAGGCACGCGCCAACATCGCCGCGGTACTGGATGCGGCCACGAATGGTGAACCGGTGGA
AATTATCCGGCGTGATGGTTCTGCCGCAGTGGTGATCAGCAAGGCTGATTTTGAGGCATACCAAAAAGCGAAATTGGATG
CGGAGTTTGATCACATCATGCAACGTCATGGCCGGACTGTTGAGGCGTTGACCGACCGATGA