Detailed information of TA system TA114624

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4729391..4730157
• Replicon: chromosome
• Accession: NZ_CP033893
• Organism: Serratia liquefaciens strain FG3

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: EGO53_RS23060
• Protein ID: WP_142816142.1
• Coordinates: 4729391..4729759 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: EGO53_RS23065
• Protein ID: WP_142816143.1
• Coordinates: 4729819..4730157 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO53_RS23035	4724469..4725206	-	738	WP_020824702.1	LuxR family transcriptional regulator	-
EGO53_RS23040	4726088..4726843	-	756	WP_020824701.1	nucleotidyltransferase domain-containing protein	-
EGO53_RS23045	4727001..4728044	-	1044	WP_142816139.1	virulence RhuM family protein	-
EGO53_RS23050	4728132..4728965	-	834	WP_142816140.1	DUF4942 domain-containing protein	-
EGO53_RS23055	4729065..4729394	-	330	WP_142816141.1	hypothetical protein	-
EGO53_RS23060	4729391..4729759	-	369	WP_142816142.1	TA system toxin CbtA family protein	Toxin
EGO53_RS23065	4729819..4730157	-	339	WP_142816143.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EGO53_RS23070	4730186..4730665	-	480	WP_142816465.1	DNA repair protein RadC	-
EGO53_RS23075	4730693..4731151	-	459	WP_142816144.1	antirestriction protein	-
EGO53_RS23080	4731332..4732567	-	1236	WP_142816145.1	O-antigen ligase family protein	-
EGO53_RS23085	4732619..4733779	-	1161	WP_142816146.1	putative lipopolysaccharide heptosyltransferase III	-
EGO53_RS23090	4734409..4734720	-	312	WP_126192610.1	hypothetical protein	-
EGO53_RS23095	4734733..4735035	-	303	WP_185959359.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4726088..4741091	15003

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (9-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13301.34 Da
• Isoelectric Point: 9.1789

>T114624 WP_142816142.1 NZ_CP033893:c4729759-4729391 [Serratia liquefaciens]
MRAIPAPPTRAAQPCPSPITVWQSLLTYLLTQHYGLTLNDTAFSDDAVIQAHLDGGSSLADALNTMVEKFDLVRIDRRGF
SSLAQSPLVVAIDILRARRACGLMTRAGYREVTRVIHGGKQP

Nucleotide

• Length: 369 bp

>T114624 NZ_CP033893:c4729759-4729391 [Serratia liquefaciens]
ATGCGAGCAATACCCGCGCCACCCACACGGGCAGCTCAGCCTTGCCCGTCGCCCATAACCGTCTGGCAATCCTTGCTCAC
CTACCTGCTGACGCAGCACTACGGCCTAACGCTCAACGACACCGCATTCAGCGACGATGCCGTGATACAGGCCCACCTCG
ATGGTGGGAGCTCCCTCGCGGATGCGCTGAATACCATGGTGGAAAAGTTTGATCTGGTACGCATTGACCGCCGGGGGTTC
AGCAGTCTGGCGCAATCGCCCCTTGTGGTCGCCATCGACATCTTGCGCGCCCGCCGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCGGGAGGTCACACGTGTAATTCACGGAGGCAAGCAACCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12714.37 Da
• Isoelectric Point: 6.6336

>AT114624 WP_142816143.1 NZ_CP033893:c4730157-4729819 [Serratia liquefaciens]
MTSTKNVPSWGLKRNVTPQFGARLVQEGERLHFLADRADISGIFSDAQRYDLEKAFPQFINHLELMLLSGELNPRHQHCV
TLYSHGLTCEADSLGSYGYVYISIYPTPETPR

Nucleotide

• Length: 339 bp

>AT114624 NZ_CP033893:c4730157-4729819 [Serratia liquefaciens]
ATGACATCGACCAAGAACGTTCCATCCTGGGGACTGAAACGCAACGTCACACCGCAGTTTGGCGCTCGCCTGGTACAGGA
GGGGGAACGACTGCATTTTCTGGCCGACCGTGCTGACATCAGCGGAATTTTCAGCGACGCACAGCGCTATGATTTGGAGA
AGGCTTTTCCGCAGTTCATCAACCACCTGGAATTGATGTTGCTCTCCGGTGAGCTCAATCCGCGTCATCAGCACTGTGTC
ACGCTGTATAGCCATGGCCTGACCTGCGAAGCCGACAGCCTGGGTTCATACGGCTACGTCTACATTTCGATTTATCCGAC
GCCTGAAACGCCCAGGTAA