Detailed information of TA system TA114623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4353234..4353814
• Replicon: chromosome
• Accession: NZ_CP033893
• Organism: Serratia liquefaciens strain FG3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A515D1D0
• Locus tag: EGO53_RS21230
• Protein ID: WP_046374632.1
• Coordinates: 4353234..4353518 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGO53_RS21235
• Protein ID: WP_142816061.1
• Coordinates: 4353527..4353814 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO53_RS21210	4348640..4349164	-	525	WP_142816058.1	NAD(P)H-dependent oxidoreductase	-
EGO53_RS21215	4349269..4350177	+	909	WP_142816059.1	LysR family transcriptional regulator	-
EGO53_RS21220	4350461..4352599	+	2139	WP_142816060.1	anaerobic ribonucleoside-triphosphate reductase	-
EGO53_RS21225	4352773..4353237	+	465	WP_116691389.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EGO53_RS21230	4353234..4353518	-	285	WP_046374632.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EGO53_RS21235	4353527..4353814	-	288	WP_142816061.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EGO53_RS21240	4353919..4354977	-	1059	WP_046374633.1	permease	-
EGO53_RS21245	4355239..4355964	+	726	WP_170868571.1	phosphonate metabolism transcriptional regulator PhnF	-
EGO53_RS21250	4355965..4356408	+	444	WP_046374634.1	phosphonate C-P lyase system protein PhnG	-
EGO53_RS21255	4356411..4356992	+	582	WP_130016099.1	phosphonate C-P lyase system protein PhnH	-
EGO53_RS21260	4356992..4358077	+	1086	WP_142816062.1	carbon-phosphorus lyase complex subunit PhnI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4343365..4353814	10449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11173.88 Da
• Isoelectric Point: 4.7160

>T114623 WP_046374632.1 NZ_CP033893:c4353518-4353234 [Serratia liquefaciens]
MRVEWDEEALRDRERIFDFLYPFNPQVAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLIVLYVVVDDVIKVL
AVVHQREKFPDIEN

Nucleotide

• Length: 285 bp

>T114623 NZ_CP033893:c4353518-4353234 [Serratia liquefaciens]
ATGCGTGTCGAATGGGATGAAGAAGCGCTACGGGACAGGGAACGTATTTTTGATTTTCTCTATCCTTTTAATCCACAGGT
TGCTGAGCAGGCTGATGCTGAGATTGATAAGGCAGTGAAGCGCCTGTTGGATTACCCTGAACTCGGTAAAATTTGGTACA
GGCAGGCGCGTAAGTTATTGGTCAGCCAGGCTTCATTAATAGTTTTATACGTTGTTGTCGACGACGTGATTAAGGTTTTA
GCCGTTGTTCATCAACGAGAGAAATTCCCCGACATAGAGAACTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11029.37 Da
• Isoelectric Point: 6.4756

>AT114623 WP_142816061.1 NZ_CP033893:c4353814-4353527 [Serratia liquefaciens]
MESRIQFRIEDETKRLAQKAADAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Nucleotide

• Length: 288 bp

>AT114623 NZ_CP033893:c4353814-4353527 [Serratia liquefaciens]
ATGGAAAGCCGTATCCAGTTTCGCATTGAGGATGAGACTAAACGTTTGGCGCAGAAAGCCGCAGACGCCAAGGGGATCAC
TTTGAGTGAGGCGTGTCGACGTTTGGCTGAGCAAATGGCGGATGAGCAACGGGCCACTGAGCAACATGAAAATTGGTTGA
AAGAAAAGGTTGATGCCGCTTTTGCCCGTTTGCATGAAGGAAGTGCGGTCTATCTTGACCAACAACAGGTTGATGAAAGC
ATGGATGCCTTTAAGGCAAAAGTCCGAGCGAAATACGACCGAAAATAA

Structures

Toxin

• AlphaFold DB: A0A515D1D0