Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2687523..2688160 Replicon chromosome
Accession NZ_CP033893
Organism Serratia liquefaciens strain FG3

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C7DFZ9
Locus tag EGO53_RS13225 Protein ID WP_049197967.1
Coordinates 2687523..2687798 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A515CX12
Locus tag EGO53_RS13230 Protein ID WP_072265813.1
Coordinates 2687795..2688160 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGO53_RS13200 2682913..2683176 + 264 WP_094859918.1 DUF3850 domain-containing protein -
EGO53_RS13205 2683176..2684219 + 1044 WP_185959412.1 phosphoadenosine phosphosulfate reductase family protein -
EGO53_RS13210 2684216..2684605 + 390 WP_142815483.1 hypothetical protein -
EGO53_RS13215 2684598..2687204 + 2607 WP_185959403.1 replication endonuclease -
EGO53_RS13220 2687207..2687428 + 222 WP_142815485.1 hypothetical protein -
EGO53_RS13225 2687523..2687798 + 276 WP_049197967.1 type II toxin-antitoxin system HicA family toxin Toxin
EGO53_RS13230 2687795..2688160 + 366 WP_072265813.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGO53_RS13235 2688596..2689651 - 1056 WP_142815486.1 phage portal protein -
EGO53_RS13240 2689653..2691374 - 1722 WP_142815487.1 terminase family protein -
EGO53_RS13245 2691534..2692367 + 834 WP_142815488.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2676895..2716298 39403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(62-114)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10153.75 Da        Isoelectric Point: 10.6115

>T114619 WP_049197967.1 NZ_CP033893:2687523-2687798 [Serratia liquefaciens]
MKEQVSALRKRQKNTLEQIFKTPVLSGIKWSDVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVVNL
REWLESIGVKP

Download         Length: 276 bp

>T114619 NZ_CP033893:2687523-2687798 [Serratia liquefaciens]
ATGAAAGAACAAGTTTCAGCGTTAAGGAAGCGGCAAAAAAACACGTTAGAACAGATATTTAAAACGCCTGTTCTCTCCGG
GATCAAATGGTCAGATGTGGAATCACTGATAAAGGCGCTGGGTGGCGAAGTCAAAGAGGGCCGCGGTTCACGTTGCAAGT
TCCTGCTTAATGGCAGCATCGCCAACTTTCACCGCCCTCACCCATCGCCGGACACGGACAAAGGCGCGGTGGTCAACCTC
CGCGAATGGCTGGAAAGCATAGGAGTTAAGCCATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13321.09 Da        Isoelectric Point: 4.9313

>AT114619 WP_072265813.1 NZ_CP033893:2687795-2688160 [Serratia liquefaciens]
MTKTAAATPNTMEIAGQPAVISFVPELGAFRGKFLGLSGYCDFVSDSIQGLKKEGEISLREYLDDCSAAGIEPYARQEKI
KTFTLRYPESFGERLNQAAAEHEVSVNAFIVETLNERMKHA

Download         Length: 366 bp

>AT114619 NZ_CP033893:2687795-2688160 [Serratia liquefaciens]
ATGACGAAGACAGCAGCAGCAACCCCAAACACCATGGAGATCGCCGGGCAACCGGCGGTAATCAGCTTTGTTCCTGAGCT
GGGCGCATTCCGCGGTAAATTCCTCGGTCTGTCCGGTTACTGCGATTTCGTTTCCGACAGCATCCAGGGGCTGAAAAAAG
AGGGCGAGATCTCTTTGCGAGAATATCTGGACGATTGCAGCGCTGCCGGTATCGAACCATACGCGCGCCAGGAGAAAATC
AAAACGTTCACCTTGCGCTACCCGGAATCGTTCGGCGAACGGCTGAACCAGGCAGCGGCAGAACATGAGGTTTCGGTCAA
TGCTTTCATCGTTGAAACCCTCAACGAGCGCATGAAACACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DFZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A515CX12

References