Detailed information of TA system TA114607

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 148575..149244
• Replicon: chromosome
• Accession: NZ_CP033893
• Organism: Serratia liquefaciens strain FG3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EGO53_RS00690
• Protein ID: WP_128865160.1
• Coordinates: 148822..149244 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: EGO53_RS00685
• Protein ID: WP_020828476.1
• Coordinates: 148575..148841 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO53_RS00660	143714..145039	+	1326	WP_122080133.1	MHS family MFS transporter	-
EGO53_RS00665	145080..145688	-	609	WP_122080132.1	HD domain-containing protein	-
EGO53_RS00670	145872..146546	+	675	WP_020828479.1	hemolysin III family protein	-
EGO53_RS00675	146711..147208	+	498	WP_020828478.1	DUF2165 domain-containing protein	-
EGO53_RS00680	147266..148252	-	987	WP_129941752.1	tRNA-modifying protein YgfZ	-
EGO53_RS00685	148575..148841	+	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
EGO53_RS00690	148822..149244	+	423	WP_128865160.1	protein YgfX	Toxin
EGO53_RS00695	149244..149939	+	696	WP_128865159.1	two-component system response regulator CreB	-
EGO53_RS00700	149936..151354	+	1419	WP_142814474.1	two-component system sensor histidine kinase CreC	-
EGO53_RS00705	151439..152803	+	1365	WP_116691813.1	cell envelope integrity protein CreD	-
EGO53_RS00710	152840..153358	-	519	WP_020828471.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16549.49 Da
• Isoelectric Point: 10.6957

>T114607 WP_128865160.1 NZ_CP033893:148822-149244 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLAKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T114607 NZ_CP033893:148822-149244 [Serratia liquefaciens]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCTGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TACGTAGCCAAAAACGCATTGCGTCGCGTCAGGGGGAGTTACGCCTGCTGGAGAACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGCCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCCTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCACCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT114607 WP_020828476.1 NZ_CP033893:148575-148841 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT114607 NZ_CP033893:148575-148841 [Serratia liquefaciens]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9