Detailed information of TA system TA114559

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 997088..997741
• Replicon: chromosome
• Accession: NZ_CP033876
• Organism: Acinetobacter baumannii strain WU_164

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EGM96_RS04760
• Protein ID: WP_025467596.1
• Coordinates: 997352..997741 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: EGM96_RS04755
• Protein ID: WP_001288210.1
• Coordinates: 997088..997345 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGM96_RS04735 (EGM96_04750)	992604..993611	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
EGM96_RS04740 (EGM96_04755)	993630..994007	+	378	WP_001216380.1	50S ribosomal protein L17	-
EGM96_RS04745 (EGM96_04760)	994189..995679	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
EGM96_RS04750 (EGM96_04765)	995728..996900	-	1173	WP_031961342.1	acyl-CoA dehydrogenase family protein	-
EGM96_RS04755 (EGM96_04770)	997088..997345	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
EGM96_RS04760 (EGM96_04775)	997352..997741	+	390	WP_025467596.1	membrane protein	Toxin
EGM96_RS04765 (EGM96_04780)	998511..999596	+	1086	WP_000049106.1	hypothetical protein	-
EGM96_RS04770 (EGM96_04785)	999674..1000240	+	567	WP_000651536.1	rhombosortase	-
EGM96_RS04775 (EGM96_04790)	1000428..1002623	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15609.84 Da
• Isoelectric Point: 10.3816

>T114559 WP_025467596.1 NZ_CP033876:997352-997741 [Acinetobacter baumannii]
MINHLNFQLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Nucleotide

• Length: 390 bp

>T114559 NZ_CP033876:997352-997741 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCGCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT114559 WP_001288210.1 NZ_CP033876:997088-997345 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT114559 NZ_CP033876:997088-997345 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7