Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 29368..29939 Replicon plasmid pAb-MCR4.3
Accession NZ_CP033872
Organism Acinetobacter baumannii strain MRSN15313

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag EGM95_RS20935 Protein ID WP_011638897.1
Coordinates 29368..29679 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag EGM95_RS20940 Protein ID WP_011638898.1
Coordinates 29679..29939 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGM95_RS20920 24846..25055 + 210 WP_034121058.1 hypothetical protein -
EGM95_RS20925 25953..26216 + 264 WP_034121059.1 hypothetical protein -
EGM95_RS20930 26258..29344 - 3087 WP_123794410.1 Tn3 family transposase -
EGM95_RS20935 29368..29679 - 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGM95_RS20940 29679..29939 - 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EGM95_RS20945 30109..30698 + 590 Protein_30 recombinase family protein -
EGM95_RS20950 30872..32497 + 1626 WP_011638903.1 phosphoethanolamine--lipid A transferase MCR-4.3 -
EGM95_RS20955 32699..33349 + 651 WP_052201470.1 HNH endonuclease -
EGM95_RS20960 33546..33749 + 204 WP_034121061.1 hypothetical protein -
EGM95_RS20965 33968..34258 + 291 WP_034121062.1 hypothetical protein -
EGM95_RS20970 34363..34599 - 237 WP_114237987.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..35502 35502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T114555 WP_011638897.1 NZ_CP033872:c29679-29368 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T114555 NZ_CP033872:c29679-29368 [Acinetobacter baumannii]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT114555 WP_011638898.1 NZ_CP033872:c29939-29679 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT114555 NZ_CP033872:c29939-29679 [Acinetobacter baumannii]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References