Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 23062..23587 Replicon plasmid pAb-MCR4.3
Accession NZ_CP033872
Organism Acinetobacter baumannii strain MRSN15313

Toxin (Protein)


Gene name relE Uniprot ID R9B9L0
Locus tag EGM95_RS20900 Protein ID WP_005134734.1
Coordinates 23062..23349 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3F3MMG8
Locus tag EGM95_RS20905 Protein ID WP_005134732.1
Coordinates 23339..23587 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGM95_RS20865 19618..19932 - 315 WP_024434403.1 BrnA antitoxin family protein -
EGM95_RS20870 19919..20206 - 288 WP_000438826.1 BrnT family toxin -
EGM95_RS20875 20579..21097 + 519 WP_000447193.1 sel1 repeat family protein -
EGM95_RS21190 21291..21425 - 135 Protein_18 DNA-binding protein -
EGM95_RS20895 22754..22897 + 144 Protein_20 DNA-directed DNA polymerase -
EGM95_RS20900 23062..23349 - 288 WP_005134734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGM95_RS20905 23339..23587 - 249 WP_005134732.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EGM95_RS20910 23590..24021 - 432 WP_123794408.1 hypothetical protein -
EGM95_RS20915 24091..24705 - 615 WP_123794409.1 recombinase family protein -
EGM95_RS20920 24846..25055 + 210 WP_034121058.1 hypothetical protein -
EGM95_RS20925 25953..26216 + 264 WP_034121059.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..35502 35502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11073.89 Da        Isoelectric Point: 10.1961

>T114554 WP_005134734.1 NZ_CP033872:c23349-23062 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPRIPKNKLSGHPNRYKIKLRSIGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDDANSRHS

Download         Length: 288 bp

>T114554 NZ_CP033872:c23349-23062 [Acinetobacter baumannii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAGCCATTAAA
GAAGAAGTTGATCAAGGTTTTGGAGAATCCTCGCATTCCCAAAAACAAGCTGTCAGGACATCCTAATCGCTACAAGATCA
AACTTCGCAGCATTGGTTATCGTTTGGTTTATGAAGTCATTGATGATGAAGTAGTTGTCATCGTAATTGCTGTAGGCAGA
CGTGAAAACAATGCCGTCTATGATGATGCCAACTCTCGTCATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9262.72 Da        Isoelectric Point: 5.0491

>AT114554 WP_005134732.1 NZ_CP033872:c23587-23339 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADTRANQKRVRVNID
DL

Download         Length: 249 bp

>AT114554 NZ_CP033872:c23587-23339 [Acinetobacter baumannii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTGGCAGG
CAAAGGTGAACCTGTTGCAATCCTCAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATCTATATGAAACGATGA
TGGAACAACTAGAAGACCTAGAACTGAATAAGATTGCAGATACTCGTGCGAACCAAAAACGCGTTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9B9L0

Antitoxin

Source ID Structure
AlphaFold DB A0A3F3MMG8

References