Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1698785..1699299 Replicon chromosome
Accession NZ_CP033865
Organism Staphylococcus aureus strain FDAARGOS_504

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag EG363_RS08985 Protein ID WP_000581791.1
Coordinates 1698785..1698994 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag EG363_RS08990 Protein ID WP_000138934.1
Coordinates 1699006..1699299 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG363_RS08965 1694674..1695744 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
EG363_RS08970 1696062..1697264 + 1203 WP_001109939.1 rod shape-determining protein RodA -
EG363_RS08975 1697425..1698108 - 684 Protein_1676 transposase -
EG363_RS08980 1698520..1698657 - 138 WP_000828354.1 hypothetical protein -
EG363_RS08985 1698785..1698994 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
EG363_RS08990 1699006..1699299 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
EG363_RS08995 1699465..1700949 + 1485 WP_000571563.1 cardiolipin synthase -
EG363_RS09000 1700977..1701624 + 648 WP_001187612.1 HD domain-containing protein -
EG363_RS09015 1701881..1702180 + 300 WP_001793952.1 hypothetical protein -
EG363_RS09020 1702337..1703209 - 873 WP_000725802.1 membrane protein insertase YidC -
EG363_RS09025 1703295..1703936 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1697425..1697601 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T114540 WP_000581791.1 NZ_CP033865:c1698994-1698785 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T114540 NZ_CP033865:c1698994-1698785 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT114540 WP_000138934.1 NZ_CP033865:c1699299-1699006 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT114540 NZ_CP033865:c1699299-1699006 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References