Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1449643..1450440 | Replicon | chromosome |
| Accession | NZ_CP033865 | ||
| Organism | Staphylococcus aureus strain FDAARGOS_504 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | EG363_RS07450 | Protein ID | WP_086153581.1 |
| Coordinates | 1449979..1450440 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | EG363_RS07445 | Protein ID | WP_001260487.1 |
| Coordinates | 1449643..1449966 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EG363_RS07380 | 1444901..1445329 | - | 429 | WP_000934793.1 | single-stranded DNA-binding protein | - |
| EG363_RS07385 | 1445329..1445967 | - | 639 | WP_001043061.1 | ERF family protein | - |
| EG363_RS07390 | 1445967..1446446 | - | 480 | WP_000002513.1 | siphovirus Gp157 family protein | - |
| EG363_RS07395 | 1446439..1446675 | - | 237 | WP_000802315.1 | hypothetical protein | - |
| EG363_RS07400 | 1446683..1446943 | - | 261 | WP_000291075.1 | DUF1108 family protein | - |
| EG363_RS07405 | 1447037..1447357 | - | 321 | WP_000219666.1 | hypothetical protein | - |
| EG363_RS07410 | 1447358..1447525 | - | 168 | WP_065317175.1 | DUF1270 domain-containing protein | - |
| EG363_RS07415 | 1447540..1447755 | - | 216 | WP_001093507.1 | DUF771 domain-containing protein | - |
| EG363_RS07420 | 1447806..1448024 | - | 219 | WP_086153579.1 | hypothetical protein | - |
| EG363_RS07425 | 1448040..1448816 | - | 777 | WP_086153580.1 | phage antirepressor KilAC domain-containing protein | - |
| EG363_RS07430 | 1448873..1449082 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| EG363_RS07435 | 1449072..1449215 | - | 144 | WP_086037489.1 | hypothetical protein | - |
| EG363_RS07440 | 1449249..1449479 | - | 231 | WP_033858173.1 | helix-turn-helix domain-containing protein | - |
| EG363_RS07445 | 1449643..1449966 | + | 324 | WP_001260487.1 | helix-turn-helix domain-containing protein | Antitoxin |
| EG363_RS07450 | 1449979..1450440 | + | 462 | WP_086153581.1 | toxin | Toxin |
| EG363_RS07455 | 1450624..1451328 | + | 705 | WP_017804779.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| EG363_RS07460 | 1451522..1452586 | + | 1065 | WP_070021279.1 | site-specific integrase | - |
| EG363_RS07505 | 1453958..1454512 | - | 555 | WP_000132893.1 | alpha/beta hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk | 1395964..1454512 | 58548 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18058.46 Da Isoelectric Point: 4.6915
>T114534 WP_086153581.1 NZ_CP033865:1449979-1450440 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELAEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELAEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T114534 NZ_CP033865:1449979-1450440 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACACGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCGGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAGTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTTGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GGCTGAGTATCTACAATTAAGTGAAGAATACATATTGGAAGCGATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACACGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCGGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAGTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTTGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GGCTGAGTATCTACAATTAAGTGAAGAATACATATTGGAAGCGATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT114534 WP_001260487.1 NZ_CP033865:1449643-1449966 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT114534 NZ_CP033865:1449643-1449966 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|