114531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 288335..288812 Replicon chromosome
Accession NZ_CP033865
Organism Staphylococcus aureus strain FDAARGOS_504

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EG363_RS01415 Protein ID WP_000052076.1
Coordinates 288335..288523 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EG363_RS01420 Protein ID WP_001059690.1
Coordinates 288552..288812 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG363_RS01385 284288..284845 + 558 WP_000824491.1 hypothetical protein -
EG363_RS01390 285186..285872 + 687 WP_001574556.1 thermonuclease family protein -
EG363_RS01395 286229..286429 + 201 WP_001059082.1 cold-shock protein -
EG363_RS01400 286926..287144 - 219 WP_000005879.1 hypothetical protein -
EG363_RS01405 287206..287490 - 285 WP_001004401.1 hypothetical protein -
EG363_RS01410 287578..288147 - 570 WP_001106663.1 hypothetical protein -
EG363_RS01415 288335..288523 - 189 WP_000052076.1 hypothetical protein Toxin
EG363_RS01420 288552..288812 - 261 WP_001059690.1 hypothetical protein Antitoxin
EG363_RS01425 289153..289356 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EG363_RS01430 289353..289589 - 237 WP_000368687.1 hypothetical protein -
EG363_RS01435 289814..290395 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
EG363_RS01440 290468..291085 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
EG363_RS01445 291241..291735 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EG363_RS01450 292134..292556 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
EG363_RS01455 292704..293420 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ant(9)-Ia / erm(A) / aph(3')-III / ant(6)-Ia - 282932..335899 52967


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T114531 WP_000052076.1 NZ_CP033865:c288523-288335 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T114531 NZ_CP033865:c288523-288335 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT114531 WP_001059690.1 NZ_CP033865:c288812-288552 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT114531 NZ_CP033865:c288812-288552 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References